بررسی پلی مورفیسم ژن IL-15 در مبتلایان به لیشمانیوز احشایی

رسولی, منوچهر (1391) بررسی پلی مورفیسم ژن IL-15 در مبتلایان به لیشمانیوز احشایی. در: The 13th Iranian & The Second International Congress of Microbiology, July 14 – 16, 2012, Ardabil - Iran.

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Official URL: http://congress.arums.ac.ir/index.php/IICM/5/sched...


IL-15 Gene Polymorphisms Are Associated with Resistance to Visceral Leishmaniasis

English Abstract

Background & Objectives: Protozoan parasites of the genus Leishmania infect millions of people worldwide causing a wide spectrum of diseases collectively termed leishmaniasis that vary in their clinical manifestations. There are several reports on the importance of IL-15 in the immunity against leishmaniasis. Since the production of IL-15, like other cytokines, is under control of its gene, we tried to find any relationship between kala azar and IL-15 genetic polymorphisms. Methods: One hundred and seventeen patients with kala-azar and 146 individuals who lived in the same area as patients and didn't have any history of leishmaniasis, joined this study. DNAs extracted from samples were genotyped for IL-15 (267C/T, 367G/A, 13687C/A, and 14035A/T) polymorphisms using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) Methods. Results: IL-15 (267) TT and T genotype and allele were significantly higher in the patients than the controls (P< 0.001 and P< 0.003, respectively). Also IL-15 (13687) CC and C genotype and allele were less frequent in the controls than the patients (P< 0.015 and P< 0.031, respectively). Haplotype analysis showed a higher frequency of 13687C/267T/367G/14035A in the patients than the controls (P< 0.000001). Conclusion: As data shown IL-15 267T allele could be considered as a susceptibility factor for kala azar. Vice versa, IL-15 13687C allele might be one of the genetic resistance factors against kala azar. In addition, we can consider the haplotype 13687C/267T/367G/14035A as a susceptibility factor for kala azar. Evaluation IL-15 level beside genetic polymorphisms is recommended.

Item Type:Conference or Workshop Item (Poster)
زبان سند : فارسی
نویسنده مسئول :منوچهر رسولی
کلیدواژه ها (انگلیسی):IL-15; Gene Polymorphisms; Resistance; Visceral Leishmaniasis
Subjects:QW Microbiology and Immunology
QX Parasitology
Divisions:Vice Chancellor for Research and Technology > Deputy for Research and Technology management and Medical Information > University of Management Conferences and Congresses
ID Code:4953
Deposited By: MS Soghra Golmaghani
Deposited On:03 Sep 1392 11:28
Last Modified:03 Sep 1392 11:28

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