مطالعه اثر ضد میکروبی آلیسین (ماده فعال موجود در عصاره سیر) بر لیزوله های سودوموناس آئروژینوزا

شکری آل هاشم, سیده خدیجه and ارزنلو, محسن and امیر مظفری, نور and رنجبر امید, مهسا and پیری دوگاهه, هادی and اکبری, معصومه (1391) مطالعه اثر ضد میکروبی آلیسین (ماده فعال موجود در عصاره سیر) بر لیزوله های سودوموناس آئروژینوزا. در: The 5th International Congress of Laboratory & Clinic, April, 23-26, 2012, Tehran.

Text - Published Version


Study of The Antimicrobial Effect of Allicin (an active component of garlic) on Pseudomonas aeroginosa.

English Abstract

Background and Aim: Pseudomonas aeroginosa is one of the most prevalent causes of nosocomial infections. This bacterium is highly resistant to most commonly used antibiotics. This has been lead to limited treatment options for this pathogen. This study was aimed to investigate the antimicrobial effect of allicin on P. aeroginosa. Methods: In this study 60 clinical isolates of P. aeroginosa and one standard strain (8821M) were included. Allicin was purified using semi preparative HPLC procedure. MIC of allicin was determined by microdilution method using serial dilutions of allicin (2-1024 μg/ml) in LB broth. The MBC was determined by subculture of the well showing no apparent growth in a Mueller-Hinton agar plate. All experiments were carried out in triplicate. The results were interpreted according to CLSI. Results: The MICs of allicin for isolates were 64 (3.33%), 128(35%) 256 (58.33%)512 (3.33%)μg/ml and the MBC values were 128 (21.66%), 256 (65%), 512 (13.33%)μg/ml. Conclusions: The results showed that allicin can inhibit the growth of P. aeroginosa.

Item Type:Conference or Workshop Item (Poster)
زبان سند : انگلیسی
نویسنده اول :سیده خدیجه شکری آل هاشم
نویسنده مسئول :محسن ارزنلو
نویسنده :نور امیر مظفری
نویسنده :مهسا رنجبر امید
نویسنده :هادی پیری دوگاهه
نویسنده :معصومه اکبری
Uncontrolled Keywords:سودوموناس آئروزینوزا ، آلیسین ، MIC ، MBC
کلیدواژه ها (انگلیسی):Pseudomonas aeruginosa , Allicin , MIC , MBC
Subjects:QV pharmacology
QW Microbiology and Immunology
WD Nutrition Disease and metabolic diseases
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Microbiology
ID Code:5017
Deposited By: Dr Mohsen Arzanlou
Deposited On:21 Sep 1392 09:15
Last Modified:31 Mar 1393 08:53

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