بررسی همبستگی پلی مورفیسم ناحیه ی غیر کد کننده ی 3’ ژن IL-16 و استعداد ابتلا به هپاتیت B مزمن

بهلگردی, عباس (1391) بررسی همبستگی پلی مورفیسم ناحیه ی غیر کد کننده ی 3’ ژن IL-16 و استعداد ابتلا به هپاتیت B مزمن. در: The 13th Iranian & The Second International Congress of Microbiology, July 14 – 16, 2012, Ardabil - Iran.

Text - Published Version

Official URL: http://congress.arums.ac.ir/index.php/IICM/5/sched...


Study of Association Between 3’ Non-coding Region Polymorphism of Interleukin-16 Gene and Chronic Hepatitis B Infection

English Abstract

Background & Objectives: IL-16 activates T-cells, macrophages, monocytes and dendritic cells by binding to CD4 molecules and it can also stimulate the production of other cytokines such as IL-6, IL-15 and tumor necrosis factor. Thus, IL-16 plays a key role in protection against immune system related infections such as Hepatitis B infection. This study was undertaken to investigate the association between IL-16 gene polymorphism rs1131445 and susceptibility to chronic Hepatitis B infection. Methods: In a case-control study, we analyzed 100 chronic HBV patients along with 100 healthy controls, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) Methods. To make sure that the results are correct, 15 samples were subject to direct sequencing. Results: Allele frequency among healthy controls and patients was determined (T: 68.5%, C: 31.5% for healthy controls and T: 69.5%, C: 30.5% for patients). Genotype frequencies TT, TC and CC among healthy controls were 49%, 39% and 12% and among patients were 47%, 45% and 8% subsequently. There was no significant association between genotype and allele frequencies and susceptibility to chronic HBV infection. Conclusion: Genotypes of rs1131445 from IL-16 gene were not associated with chronic HBV infection in Iranian population of this study. So rs1131445 gene polymorphism cannot be a prognostic factor for Iranian patients with chronic Hepatitis B infection.

Item Type:Conference or Workshop Item (Poster)
زبان سند : انگلیسی
نویسنده مسئول :عباس بهلگردی
کلیدواژه ها (انگلیسی):Genotype ; Allele Frequencies
Subjects:QW Microbiology and Immunology
QZ Pathology
WI Digestive System
Divisions:Vice Chancellor for Research and Technology > Deputy for Research and Technology management and Medical Information > University of Management Conferences and Congresses
ID Code:5093
Deposited By: MS Soghra Golmaghani
Deposited On:03 Oct 1392 10:07
Last Modified:03 Oct 1392 10:07

Repository Staff Only: item control page

Document Downloads

More statistics for this item...