title

اثر حفاظتی عصاره زردچوبه بر روی آسیب های القاء شده با متوترکسات و استرس کسیداتیو

رضایی مقدم, عادل ، مهاجری, داریوش ، نام آوران عباس آباد, علی ، منافی, حامد ، شاهی, دلاور ، مأذنی, محمد (1392) اثر حفاظتی عصاره زردچوبه بر روی آسیب های القاء شده با متوترکسات و استرس کسیداتیو. Chinese Journal of Natural Medicines ــ 11 (5). ص.ص.477-483. شاپا 1672-3651

[img] متنی - نسخه چاپ شده
محدود به فقط پرسنل سامانه

6MB
[img]
پیش نمایش
متنی - نسخه چاپ شده
231kB

آدرس اینترنتی رسمی : http://www.elsevier.com/journals/chinese-journal-o...


عنوان انگليسي

Protective effect of turmeric extract on ethotrexate-induced intestinal damage and oxidative stress

خلاصه انگلیسی

Aim The most important side effect of methotrexate (MTX) is mucositis. The purpose of this study was to evaluate the effect of turmeric extract on intestinal damage and oxidative stress in rats receiving methotrexate. Methods Experiments were performed on male Wistar albino rats divided into six groups. First group received normal saline orally, the second group received turmeric extract (100 mg·kg−1) orally for 30 days, the third group received turmeric extract (200 mg·kg−1) orally for 30 days, the fourth group received a single dose of methotrexate (20 mg·kg−1) i.p. at day 30, the fifth group received turmeric extract (100 mg·kg−1) orally for 30 days and a single dose of methotrexate (20 mg·kg−1) i.p. at day 30, and the sixth group received turmeric extract (200 mg·kg−1) orally for 30 days and single dose of methotrexate (20 mg·kg−1) i.p. at day 30. Four days after methotrexate injection, animals were anesthetized, blood samples were taken to determine total antioxidant status (TAS) and jejunum samples were taken for glutathione peroxidase (GPx), superoxidase dismutase (SOD), catalase (CAT), aldehyde malondialdehyde (MDA), and histopathological assessment. Results Microscopic evaluation from intestinal tissues of the MTX treated group, showed severe villus shortening and blunting, inflammatory cell infiltration and hemorrhage in lamina propria, along with epithlial cell necrosis. Levels of SOD, GSH-Px and CAT decreased in the MTX received group, but increased significantly (P < 0.05) in the turmeric + MTX groups. MTX increased lipid peroxidation, however, turmeric decreased peroxidation significantly (P < 0.05). Conclusion These results suggest that turmeric extract may protect the small intestine of rats from methotrexate-induced damage. Turmeric effects could result from its antioxidant properties.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :عادل رضایی مقدم
نویسنده مسئول :محمد مأذنی
اطلاعات اضافی :Indexed in: Science Citation Index Expanded , PubMed, MEDLINE, BIOSIS Previews , Index medicus , EMBASE , Global Health , International Pharmaceutical Abstracts , IPA Toxicology , SCOPUS , Chemical Abstracts , Index Copernicus
کلیدواژه ها (انگلیسی):Turmeric ; Methotrexate ; Intestinal damage ; Oxidative stress
موضوعات :QU بیوشیمی
QV فارماکولوژی
WI سیستم گوارشی
بخش های دانشگاهی :دانشكده پزشكي > گروه علوم پایه > بخش بیوشیمی
کد شناسایی :5124
ارائه شده توسط : دکتر محمد مأذنی
ارائه شده در تاریخ :07 دی 1392 09:28
آخرین تغییر :10 مهر 1393 08:34

فقط پرسنل کتابخانه صفحه کنترل اسناد

Document Downloads

More statistics for this item...