تاثیر ویتامین ث بر روی اکسیداسیون لیپید، آسیب عضلانی و التهاب بعد از ۳۰ دقیقه فعالیت در ۷۵٪ VO2max

نخستین روحی, بابک and بابایی, پروین and رحمانی نیا, فرهاد and بهلولی, شهاب (1387) تاثیر ویتامین ث بر روی اکسیداسیون لیپید، آسیب عضلانی و التهاب بعد از ۳۰ دقیقه فعالیت در ۷۵٪ VO2max. The Journal of sports medicine and physical fitness ــ 48 (2). pp. 217-24. شاپا 0022-4707

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Effect of vitamin C supplementation on lipid peroxidation, muscle damage and inflammation after 30-min exercise at 75% VO2max.

English Abstract

AIM: Hypothetically, supplementation with the antioxidant vitamins C could alleviate exercise-induced lipid peroxidation. The purpose of this study was to evaluate the effect of vitamin C supplementation on exercise-induced lipid peroxidation, muscle damage and inflammation. METHODS: Sixteen healthy untrained male volunteers participated in a 30-min exercise at 75% Vo2max. Subjects were randomly assigned to one of two groups: 1) placebo and 2) vitamin C (VC: 1 000 mg vitamin C). Blood samples were obtained prior to supplementation (baseline), 2 h after supplementation (immediately pre-exercise), post-exercise, 2 and 24 h after exercise. Plasma levels of VC, total antioxidant capacity (TAC), creatine kinase (CK), malondealdehyde (MDA), total leukocytes, neutrophils, lymphocytes, interleukin-6 (IL-6) and cortisol were measured. RESULTS: Plasma vitamin C concentrations increased significantly in the VC in response to supplementation and exercise (P<0.05). TAC decreased significantly in Placebo group 24 h after exercise compared to pre-exercise (P<0.05). Although MDA levels were similar between groups at baseline, it increased significantly 2 h after exercise only in the Placebo group (P<0.05). CK increased immediately and 2 h after exercise in both groups and 24 h after exercise only in placebo group compared to pre-exercise (P<0.05). Markers of inflammation (total leukocyte counts, neutrophil counts and IL-6) were increased significantly in response to the exercise (P<0.05). In VC group, there was significant increase in lymphocyte counts immediately after exercise compared with pre-exercise (P<0.05). Serum cortisol concentrations significantly declined after supplementation compared with baseline (P<0.05) as well as declined 2 and 24 h after exercise compared with immediately after exercise in VC group (P<0.05). CONCLUSION: VC supplementation prevented endurance exercise-induced lipid peroxidation and muscle damage but had no effect on inflammatory markers.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :بابک نخستین روحی
Additional Information:Impact Factor 0,695 Indexed/Abstracted in: 1-ISI,Medline/Pubmde, 2-Chemical Abstracts, 3-CINAHL, Current Contents/Clinical Medicine, Excerpta Medica (EMBASE), Focus On: Sports Science & Medicine SM, MDS, Physical Education Index, Research Alert, Sport Database, SPORT Discus
کلیدواژه ها (انگلیسی):Vitamin C ; Exercise ; Inflammation ; Supplementation ; Malondealdehyde
Subjects:QV pharmacology
QT physiology
QU Biochemistry
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Pharmacology
ID Code:515
Deposited By: Dr Shahab Bohlooli
Deposited On:20 Sep 1388 16:16
Last Modified:17 Nov 1391 10:51

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