الگوی مقاومت آنتی بیوتیکی اسینتو باکتر بومانی های جدا شده ازعفونت های بیمارستانی در اراک- ایران

ژاپونی نژاد, علیرضا and غزنوی راد, احسان الله and آموزنده, علیرضا and صوفیان, معصومه (1391) الگوی مقاومت آنتی بیوتیکی اسینتو باکتر بومانی های جدا شده ازعفونت های بیمارستانی در اراک- ایران. در: The 13th Iranian & The Second International Congress of Microbiology, July 14 – 16, 2012, Ardabil - Iran.

Text - Published Version

Official URL: http://congress.arums.ac.ir/index.php/IICM/5/sched...


Antibiotic Resistance Profile of Acinetobacter Baumannii Isolated from Nosocomial Outbreak in Arak-Iran

English Abstract

Background & Objectives: In the last decade, Acinetobacter baumannii have become one of the most important pathogens responsible for nosocomial infections, especially in Intensive Care Unit patients. The emergence and rapid spread of carbapenem-resistant Acinetobacter baumannii has been reported worldwide. From August 2011 to September 2012 a nosocomial outbreak has been occurred in ICU wards of a central teaching hospital , caused prolonged hospitalization and considerable morbidity. The purpose of the present study was to investigate phenotypic characterization of Acinetobacter baumannii isolated from clinical and environmental specimens obtained during the time of the study. Methods: A total of 60 non-duplicate Acinetobacter baumani isolates were collected from clinical and environmental specimens of central teaching hospital between August 2011 and September 2012. All isolates were identified as Acinetobacter baumannii by standard biochemical tests and microgen kit (microgen bioproducts). In addition phenotypical characterization of A. baumannii was confirmed by the presence of 16S–23S rRNA specific gene intergenic spacer (ITS). Susceptibilities of the bacterial isolates to panel 22 antimicrobial agents (Mast ,UK) were tested using the standard disk diffusion methods according to Clinical and Laboratory Standards Institute(CLSI-2011 ), European Committee on Antimicrobial Susceptibility Testing(Ucast-2011) and British Society for Antimicrobial Chemotherapy (BSAC-2011) guideline. Results: Acinetobacter baumannii isolates showed high rate of resistant to ceftazidime (100%), cefotaxime (100%), cefepime(100%), cefoxitin(100%), chloramphenicol(100%), ciprofloxacin(100%), levofloxacin(100%), erythromycin(100%), clindamaycin(100%) , rifampicin(100%), ceftriaxone(100%), aztreonam(100%), piperacillin(100%), piperacillin/tazobactam(100%), Trimethoprim-sulfamethoxazole(100%), gentamicin(98.3%), meropenem(96.6%), tigecycline(91.6%), imipenem(86.6%), tetracycline(84%), amikacin(84%). Nevertheless netilmicin and colistin illustrated 57% and 7% respectively. Conclusion: High prevalence extensively drug resistant (XDR) strains in this hospital indicating the antibiotic resistant is a major concern, hence antibiotic prescription policy should be revised and infection control measure is necessary to be improved.

Item Type:Conference or Workshop Item (Speech)
زبان سند : انگلیسی
نویسنده مسئول :علیرضا ژاپونی نژاد
کلیدواژه ها (انگلیسی):Antibiotic Resistance ; Acinetobacter ; Nosocomial
Subjects:QW Microbiology and Immunology
WX Hospital and other health Facilities
Divisions:Vice Chancellor for Research and Technology > Deputy for Research and Technology management and Medical Information > University of Management Conferences and Congresses
ID Code:5214
Deposited By: MS Soghra Golmaghani
Deposited On:16 Oct 1392 11:59
Last Modified:16 Oct 1392 11:59

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