title

نقش تغذیه و سایر عوامل محیطی در ابتلا به سرطان معده در ایران - مطالعه مبتنی بر جامعه

پورفرضی, فرهاد and ویلن, آنا and کالدور, جان and ملک زاده, رضا (1388) نقش تغذیه و سایر عوامل محیطی در ابتلا به سرطان معده در ایران - مطالعه مبتنی بر جامعه. international journal of cancer ــ 125 (8). pp. 1953-1960. شاپا 0020-7136

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Title

The role of diet and other environmental factors in the causation of gastric cancer in Iran—A population based study

English Abstract

Despite a declining trend in the incidence of gastric cancer (GC), it is still a major global public health concern of the 21st century. The rates of GC reported from Ardabil Province, Iran, are among the highest in the world. To investigate risk factors for GC in Ardabil, we undertook a population-based case-control study. The study aimed to recruit all Ardabil residents newly diagnosed with GC in the time period of 2004–2005, and 2 controls per case. Participants were interviewed using a structured questionnaire. Ten milliliters of blood was collected for blood grouping and investigating the presence of IgG antibodies against Helicobacter pylori. During the study period, 217 people with GC and 394 controls were recruited. In multivariate analysis, diet and Helicobacter pylori infection (OR 5 2.41; 95% CI: 1.35–4.32) were found to be the factors that were most strongly related to GC. High intake of Allium vegetables (OR 5 0.35) and fruit, especially citrus fruit (OR 5 0.31) and consumption of fresh fish (OR 5 0.37) were significantly protective. On the other hand, consumption of red meat (OR 5 3.40) and dairy products (OR 5 2.28) were positively associated with the risk of GC. People who had a preference for higher salt intake (OR 5 3.10) and drinking strong and hot tea (OR 5 2.64 and 2.85, respectively) were at higher risk. In conclusion, Helicobacter pylori infection as measured by serum IgG as well as the consumption of red meat and dairy products increases the risk of GC in Ardabil, while the intake of fresh fruit and fresh fish decrease the risk.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :فرهاد پورفرضی
نویسنده :رضا ملک زاده
Additional Information:2008 Impact Factor: 4.734 Indexing: 1- MEDLINE /PubMed -ISI 2-Scopus
کلیدواژه ها (انگلیسی):gastric cancer ; Helicobacter pylori ; lifestyle ; occupation ; diet
Subjects:WI Digestive System
QZ Pathology
WD Nutrition Disease and metabolic diseases
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
ID Code:522
Deposited By: Dr Farhad Pourfarzi
Deposited On:24 Sep 1388 05:42
Last Modified:15 Nov 1391 14:42

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