شیوع بیماری سل MDR در میان جمعیت ایران

اله یار ترکمن, محمدرضا and شیخ الاسلام, فاطمه مریم and فرنیا, پریسا and شاه حسینی, محمدحسن and درخشانی نظهد, زهرا and ولایتی, علی اکبر (1391) شیوع بیماری سل MDR در میان جمعیت ایران. در: The 13th Iranian & The Second International Congress of Microbiology, July 14 – 16, 2012, Ardabil - Iran.

Text - Published Version

Official URL: http://congress.arums.ac.ir/index.php/IICM/5/sched...


MDR Tuberculosis Outbreak among Iranian Population

English Abstract

Background & Objectives: Iran has a high incidence of tuberculosis (TB) including drug resistant cases. Inappropriate use of anti-TB drugs is risk factor for further development of multidrug resistant (MDR)-TB. We carried out an investigation to anti-tuberculosis drug in Iran, aim to prepare and trace MDR cases and choose better strategy to counter MDR tuberculosis. Patients with MDR-TB are treated with anti-tuberculosis regimens and also arranged by spoligotyping methods. Methods: In this study, 102 tuberculosis patients were assessed using microscopic evaluation, culture and antibiogram include INH, RIF, SM, ETM and PIZ. Results: 58.6% INH resistant, 42.6% for RIF, 15.8% for SM, 28% for ETM and 33.33% were resistant to PIZ. other part of research belong to spoligotyping clustering that separated specimen to Haarlem (30%),CAS (28%), T family (14%), Beijing (11%), MANU2 (8%) and LAM (3%) that are analyzed simultaneously with antibiogram result. Overall, being resistant to first line drug mentioned above showed: 27% resistant for Haarlem, 34% for CAS, 41% for T, 54% for Beijing, 74% for MANU2 and 26% were resistant to LAM. Our result showed that MANU2 (8%) is considerably more than average rate in spoligobank (0.04%) before, beside high rate of resistance for Beijing and specially MANU2 that were unexpected. Conclusion: This result show needs for pay attention to antibiotic resistance that led to MDR and XDR resistant tuberculosis. On the other hand, MANU2 as a high potential epidemiologic cluster of M.tuberculosis need to be more investigated.

Item Type:Conference or Workshop Item (Poster)
زبان سند : انگلیسی
نویسنده مسئول :محمدرضا اله یار ترکمن
کلیدواژه ها (انگلیسی):Tuberculosis ; MRD ; Spoligotyping
Subjects:QW Microbiology and Immunology
WC Communicable Diseases
Divisions:Vice Chancellor for Research and Technology > Deputy for Research and Technology management and Medical Information > University of Management Conferences and Congresses
ID Code:5233
Deposited By: MS Soghra Golmaghani
Deposited On:17 Oct 1392 09:39
Last Modified:17 Oct 1392 09:39

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