حسینی اصل, سید سعید ، مأذنی, محمد ، پورفرضی, فرهاد (1392) بررسی ارتباط میان چندریختی MTHFR C677T و استعداد ابتلا به سرطان معده در استان اردبیل. [ طرح تحقیقاتی]
متن کامل
متنی (گزارش نهایی بصورت مقاله ارائه شده است)
- گزارش نهایی طرح تحقیقاتی/ پایان نامه
محدود به فقط پرسنل سامانه 90kB |
عنوان انگليسی
Decrease in gastric cancer susceptibility by MTHFR C677T polymorphism in Ardabil Province, Iran
خلاصه انگلیسی
Background/aims: Gastric cancer, as the fourth most frequent malignancy worldwide, has the highest rate among cancer-related disorders in Ardabil province, located in North-West Iran. Methylene tetrahydrofolate reductase is one of the cancer susceptibility genes with considerable polymorphisms. Methylene tetrahydrofolate reductase C677T leads to a decrease of about 30% in its product activity and is reported to have an effect on cancer susceptibility. Materials and Methods: Methylene tetrahydrofolate reductase C677T genotyping was carried out by polymerase chain reaction-restriction fragment length polymorphism on peripheral blood DNA from 76 gastric cancer patients and 91 healthy controls. The statistical significance was calculated by logistic regression analysis. Results: The mean age was 64.2±11.1 and 62.1±9.8 years for cases and controls, respectively. Among tumors, 35.5% were diffuse type and others were intestinal. The frequency of genotypes was 61.8%, 32.9%, and 5.3% among cases and 45.1%, 50.6%, and 4.4% among controls for Ala/Ala, Ala/Val, and Val/Val, respectively. CT heterozygotes had lower susceptibility to gastric cancer (p=0.02). This relationship of significance was detected considering gender and age. Conclusions: It was found that T allele has a protective association with age in the Ardabil province.
نوع سند : | طرح تحقیقاتی |
---|---|
زبان سند : | انگلیسی |
وضعیت پروژه : | اتمام یافته |
مجری اصلی : | سید سعید حسینی اصل |
سایر مجریان : | محمد مأذنی |
همکار طرح : | فرهاد پورفرضی |
موضوعات : | QY آسیب شناسی بالینی WI سیستم گوارشی |
بخش های دانشگاهی : | دانشكده پزشكي > گروه علوم پایه > بخش ژنتیک دانشكده پزشكي > گروه اطفال ، پزشکی اجتماعی دانشكده پزشكي > گروه علوم پایه > بخش بیوشیمی |
کد شناسایی : | 5237 |
ارائه شده توسط : | دکتر سید سعید حسینی اصل |
ارائه شده در تاریخ : | 19 دی 1392 08:21 |
آخرین تغییر : | 19 دی 1392 08:21 |
فقط پرسنل کتابخانه صفحه کنترل اسناد