اثرات کلوفیبرات در هیپربیلی روبینمی نوزادان ترم

حبیبی, مرتضی ، مهریار, ابوالفضل ، ایازی, پرویز ، احمدآبادی, فرزاد ، جوادی, امیر (1390) اثرات کلوفیبرات در هیپربیلی روبینمی نوزادان ترم. Acta Medica Iranica ــ 50 (1). ص.ص.21-25. شاپا 0044-6025

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عنوان انگليسي

The Effect of Clofibrate on Hyperbilirubinemia of Term Neonates

خلاصه انگلیسی

Abstract- Clofibrate is a glucuronosyl transferase inducer that has been proposed to increase the elimination of bilirubin in neonates with hyperbilirubinemia. This study was conducted to determine the therapeutic effect of clofibrate in term neonates with non-hemolytic jaundice. This study was conducted on 52 newborns with pathologic unconjugated jaundice in Qazvin children hospital. Newborns divided randomly in two groups. Case group treated with clofibrate and intensive phototherapy, while control group treated only with intensive phototherapy. Serum bilirubin level was measured before and 6, 12, 24 and 48 hours after treatment. Results were compared and analyzed. The mean serum level of bilirubin before treatment in the case and control groups were 20.78±2.38 and 20.52±2.44 mg/dl, respectively (P=0.69). The mean serum level of bilirubin in 6, 12, 24 and 48 hours after treatment in the case group were 18.20±2.20, 14.70±2.06, 10.72±2.40 and 8.90±0.83 mg/dl , respectively. These values in control group were 18.26±2.42, 15.36±2.59, 12.29±2.28 and 10.23±1.50 mg/dl, respectively. There was significant difference between two groups regarding mean serum level of bilirubin 24 hours (P=0.019) and 48 hours after treatment (P=0.005). In conclusion, clofibrate was effective in reducing neonatal jaundice and its effect appeared 24 hours after treatment. © 2012 Tehran University of Medical Sciences. All rights reserved

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :مرتضی حبیبی
نویسنده مسئول :ابوالفضل مهریار
نویسنده :پرویز ایازی
نویسنده :فرزاد احمدآبادی
نویسنده :امیر جوادی
اطلاعات اضافی :Indexing in: Medline, PubMed, Scopus,ProQuest, Scientific Information Database (SID),Embase , EBSCOhost, Directory of Open Access Journals (DOAJ), Directory of Research Journal Indexing (DRJI), Google Scholar, , Index Copernicus, Index Medicus for Eastern Mediterranean Region (IMEMR), IranMedex , Islamic World Science Citation Center (ISC), Magiran,
کلید واژه ها (انگلیسی):clofibrate , hyperbillirubinemia , neonatal
موضوعات :WS بیماریهای کودکان
بخش های دانشگاهی :دانشكده پزشكي > گروه اطفال ، پزشکی اجتماعی
کد شناسایی :5284
ارائه شده توسط : دکتر فرزاد احمدآبادی
ارائه شده در تاریخ :10 آذر 1393 04:21
آخرین تغییر :10 آذر 1393 04:21

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