اثرات کلوفیبرات در هیپربیلی روبینمی نوزادان ترم

حبیبی, مرتضی and مهریار, ابوالفضل and ایازی, پرویز and احمدآبادی, فرزاد and جوادی, امیر (1390) اثرات کلوفیبرات در هیپربیلی روبینمی نوزادان ترم. Acta Medica Iranica ــ 50 (1). pp. 21-25. شاپا 0044-6025

Text - Published Version

Official URL: http://acta.tums.ac.ir/index.php/acta/article/view...


The Effect of Clofibrate on Hyperbilirubinemia of Term Neonates

English Abstract

Abstract- Clofibrate is a glucuronosyl transferase inducer that has been proposed to increase the elimination of bilirubin in neonates with hyperbilirubinemia. This study was conducted to determine the therapeutic effect of clofibrate in term neonates with non-hemolytic jaundice. This study was conducted on 52 newborns with pathologic unconjugated jaundice in Qazvin children hospital. Newborns divided randomly in two groups. Case group treated with clofibrate and intensive phototherapy, while control group treated only with intensive phototherapy. Serum bilirubin level was measured before and 6, 12, 24 and 48 hours after treatment. Results were compared and analyzed. The mean serum level of bilirubin before treatment in the case and control groups were 20.78±2.38 and 20.52±2.44 mg/dl, respectively (P=0.69). The mean serum level of bilirubin in 6, 12, 24 and 48 hours after treatment in the case group were 18.20±2.20, 14.70±2.06, 10.72±2.40 and 8.90±0.83 mg/dl , respectively. These values in control group were 18.26±2.42, 15.36±2.59, 12.29±2.28 and 10.23±1.50 mg/dl, respectively. There was significant difference between two groups regarding mean serum level of bilirubin 24 hours (P=0.019) and 48 hours after treatment (P=0.005). In conclusion, clofibrate was effective in reducing neonatal jaundice and its effect appeared 24 hours after treatment. © 2012 Tehran University of Medical Sciences. All rights reserved

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :مرتضی حبیبی
نویسنده مسئول :ابوالفضل مهریار
نویسنده :پرویز ایازی
نویسنده :فرزاد احمدآبادی
نویسنده :امیر جوادی
Additional Information:Indexing in: Medline, PubMed, Scopus,ProQuest, Scientific Information Database (SID),Embase , EBSCOhost, Directory of Open Access Journals (DOAJ), Directory of Research Journal Indexing (DRJI), Google Scholar, , Index Copernicus, Index Medicus for Eastern Mediterranean Region (IMEMR), IranMedex , Islamic World Science Citation Center (ISC), Magiran,
کلیدواژه ها (انگلیسی):clofibrate , hyperbillirubinemia , neonatal
Subjects:WS Pediatrics
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
ID Code:5284
Deposited By: Dr Farzad Ahmadabadi
Deposited On:10 Sep 1393 04:21
Last Modified:10 Sep 1393 04:21

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