سلولهای بنیادی فولیکول مو بعد از ضایعه نخاعی متمایز می شود و باعث بهبودی می شود

نجف زاده, نوروز and نوبخت, ملیحه and پورحیدر, باقر and گل محمدی, محمد قاسم (1392) سلولهای بنیادی فولیکول مو بعد از ضایعه نخاعی متمایز می شود و باعث بهبودی می شود. Neural Regeneration Research ــ 8 (36). pp. 3365-3372. شاپا 1673-5374

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Rat hair follicle stem cells differentiate and promote recovery following spinal cord injury

English Abstract

Emerging studies of treating spinal cord injury (SCI) with adult stem cells led us to evaluate the effects of transplantation of hair follicle stem cells in rats with a compression-induced spinal cord lesion. Here, we proposed a hypothesis that rat hair follicle stem cell transplantation can promote the recovery of injured spinal cord. Compression-induced spinal cord injury was induced in Wistar rats in this study. The bulge area of the rat vibrissa follicles was isolated, cultivated and characterized with nestin as a stem cell marker. 5-Bromo-2′-deoxyuridine (BrdU) labeled bulge stem cells were transplanted into rats with spinal cord injury. Immunohistochemical staining results showed that some of the grafted cells could survive and differentiate into oligodendrocytes (receptor-interacting protein positive cells) and neuronal-like cells (βIII-tubulin positive cells) at 3 weeks after transplantation. In addition, recovery of hind limb locomotor function in spinal cord injury rats at 8 weeks following cell transplantation was assessed using the Basso, Beattie and Bresnahan (BBB) locomotor rating scale. The results demonstrate that the grafted hair follicle stem cells can survive for a long time period in vivo and differentiate into neuronal- and glial-like cells. These results suggest that hair follicle stem cells can promote the recovery of spinal cord injury.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :نوروز نجف زاده
نویسنده :ملیحه نوبخت
نویسنده :باقر پورحیدر
نویسنده :محمد قاسم گل محمدی
Additional Information:Impact Factor: 0.144 Indexed in: ISI, Scopus, PubMed/PMC, Embase, DOAJ
کلیدواژه ها (انگلیسی):neural regeneration; spinal cord injury; cell transplantation; cell therapy; hair follicle stem cells; oligodendrocytes; nerve cells; glial cells; receptor-interacting protein; grants-supported paper; neuroregeneration
Subjects:QS Human Anatomy
WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Anatomy
ID Code:5309
Deposited By: Dr Nowruz Najafzadeh
Deposited On:30 Oct 1392 10:39
Last Modified:31 Jan 1400 13:20

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