title

برهمکنش مفنامیک اسید با یون های کبالت 2+ در محیط آبی: آنالیز کلاسیک و سطح پاسخ

ادریسی, محمد and رزاقی اصل, نیما and مجیدی, بهروز (1387) برهمکنش مفنامیک اسید با یون های کبالت 2+ در محیط آبی: آنالیز کلاسیک و سطح پاسخ. Turkish Journal of Chemistry ــ 32 (1). pp. 505-519. شاپا 1300-0527

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Title

Interaction of Mefenamic Acid with Cobalt(II) Ions in Aqueous Media: Evaluation via Classic and Response Surface Methods

English Abstract

Mefenamic acid reacts with cobalt(II) ions in aqueous alkaline medium to form a highly stable deep brown complex at ambient temperature. The complexation process was optimized in terms of pH, temperature, agitation rate, and contact time using classical studies. A response surface method based on Box-Behnken design was used to statistically model the complexation reaction and investigate factor effects along with their interactions. A quadratic model was developed using experimental data with a correlation coefficient of 0.9609. Numerical optimization was performed to achieve the optimum solutions of factor combinations. The results of the classical investigation and statistical method were in close agreement with each other, while the advantages of the modern experimental design method over conventional one-factor-at-a-time studies were revealed.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :محمد ادریسی
نویسنده مسئول :نیما رزاقی اصل
نویسنده :بهروز مجیدی
Additional Information:Indexing in: Chemical Abstracts Service , EBSCOhost , Scopus ,
کلیدواژه ها (انگلیسی):Mefenamic acid; cobalt; Box-Behnken; complexation; classical method
Subjects:QV pharmacology > QV 744 Medicinal Chemistry
Divisions:School of Pharmacy > Department of Medicinal Chemistry
ID Code:5382
Deposited By: Dr Nima Razzaghi-Asl
Deposited On:10 Sep 1393 04:47
Last Modified:10 Sep 1393 04:47

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