ارزیابی اثر فاکتورها در برهمکنش سیپروفلوکساسین و یون های فریک

ادریسی, محمد and رزاقی اصل, نیما and درگاهی, صدیقه (1391) ارزیابی اثر فاکتورها در برهمکنش سیپروفلوکساسین و یون های فریک. International Journal of Research in Chemistry and Environment ــ 2 (1). pp. 242-250. شاپا 2248-9649

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Official URL: http://www.ijrce.org/back_details.php?id=181


Factor Effect Estimation in Ciprofloxacin-Iron Interaction

English Abstract

Interaction of drug molecules with exogenous substances such as metal ions is of significant importance from both physiological and pharmaceutical aspects of view. The effects of different variables on complex formation between ciprofloxacin and Iron (III) ions were evaluated and compared via facile modern statistical techniques such as Response Surface Methodology (RSM), Ruggedness testing, Factorial design and Taguchi method. Results of all methods were in relatively good agreement with each other and revealed that contact time of the reactants and pH may play more important roles in complex formation between ciprofloxacin and ferric ions.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :محمد ادریسی
نویسنده :نیما رزاقی اصل
نویسنده :صدیقه درگاهی
کلیدواژه ها (انگلیسی):Ciprofloxacin, Ruggedness, Complexation, Box-Behnken design
Subjects:QV pharmacology > QV 744 Medicinal Chemistry
Divisions:School of Pharmacy > Department of Medicinal Chemistry
ID Code:5385
Deposited By: Dr Nima Razzaghi-Asl
Deposited On:10 Sep 1393 07:12
Last Modified:10 Sep 1393 07:23

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