سنتز و بررسی خاصیت ضد سرطانی مشتقات ایمیدازولی ایندنو{1و2-b}کینولین-9و11-دی ان

سرکارزاده, هستی and میری, رامین and فیروزی, امیدرضا and امینی, محسن and رزاقی اصل, نیما and ادراکی, نجمه and شفیعی, عباس (1391) سنتز و بررسی خاصیت ضد سرطانی مشتقات ایمیدازولی ایندنو{1و2-b}کینولین-9و11-دی ان. Archives of Pharmacal Research ــ 36 (4). pp. 436-447. شاپا 1976-3786

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Official URL: http://link.springer.com/article/10.1007%2Fs12272-...


Synthesis and antiproliferative activity evaluation of imidazole-based indeno[1,2-b]quinoline-9,11-dione derivatives

English Abstract

A series of new imidazole substituted indeno[1,2-b]quinoline-9,11-dione derivatives were synthesized and evaluated for their antiproliferative effects on HeLa, LS180, MCF-7 and Jurkat human cancer cell lines. Antiproliferative effects were evaluated using MTT assay. Prepared compounds exhibited weak to good antiproliferative activity in evaluated cell lines. Prepared compounds were more potent in Jurkat cell line when compared to LS180, HeLa and MCF-7 cell lines. Compounds 29 (IC16 = 0.7 μM) and 31 (IC16 = 1.7 μM) and 33 (IC16 = 1.7 μM) were found to be the most potent molecules on Jurkat cell lines. Moreover; it was found that some of the tested compounds bearing imidazole-2-yl moiety on the C11-position of dihydropyridine ring exhibited superior antiproliferative activity in comparison to cis-platin especially in Jurkat cell line (compounds 29, 31, and 33). It seemed that the introduction of electron-withdrawing groups on the imidazole ring enhanced the antiproliferative potential of these compounds (compounds 27, 29 and 31). The results of this study proposed that some of the imidazole substituted indeno[1,2-b]quinoline-9,11-dione compounds may act as efficient anticancer agents in vitro, emphasizing their potential role as a source for rational design of potent antiproliferative agents.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :هستی سرکارزاده
نویسنده :رامین میری
نویسنده :امیدرضا فیروزی
نویسنده :محسن امینی
نویسنده :نیما رزاقی اصل
نویسنده :نجمه ادراکی
نویسنده مسئول :عباس شفیعی
Additional Information:2013 Impact Factor : 1.751 Abstracted/Indexed in: Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, CSA, CAB International, Academic OneFile, Biological Abstracts, BIOSIS, CAB Abstracts, Current Contents/ Life Sciences, Expanded Academic, Global Health, International Pharmaceutical Abstracts, OCLC, Reaxys, SCImago, Summon by ProQuest
Uncontrolled Keywords:سنتز-ایندنو{1و2-b} کینولین-9و11-دی ان-ضد سرطان-روش متیل تیازول تترازولیوم
کلیدواژه ها (انگلیسی):, Synthesis, Indeno[1,2-b]quinoline-9, 11-dione Antiproliferative, MTT assay
Subjects:QV pharmacology > QV 744 Medicinal Chemistry
QZ Pathology
Divisions:School of Pharmacy > Department of Medicinal Chemistry
ID Code:5396
Deposited By: Dr Nima Razzaghi-Asl
Deposited On:10 Aug 1393 10:11
Last Modified:10 Aug 1393 10:11

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