آیا رابطه بین ایدیوپاتیک یووئیت و تب مدیترانه ای فامیلی وجود دارد؟

صالح زاده, فرهاد and یثربی, سیده عذرا and حسینی, مهسا and حسینی, مریم (1392) آیا رابطه بین ایدیوپاتیک یووئیت و تب مدیترانه ای فامیلی وجود دارد؟. Autoimmune Diseases ــ 2014 (2014). pp. 1-3. شاپا 2090-0422

Text - Published Version

Official URL: http://www.hindawi.com/journals/ad/2014/238931/


Idiopathic Uveitis and Familial Mediterranean Fever: Is There Any Relationship

English Abstract

Introduction. Familial Mediterranean fever (FMF) is an auto-inflammatory disease characterized by attacks of fever and polyserositis. FMF is often associated with other autoimmune diseases such as rheumatoid arthritis, polyarteritis nodosa (PAN), and Behcet. Uveitis is an inflammatory process caused by underlying infectious and inflammatory disorders. This study investigates the probable relationship between idiopathic uveitis and FMF. Methods. Patients with idiopathic uveitis were analyzed for the 12 most common MEFV mutations (P369S, F479L, M680I(G/C), M680I(G/A), I692del, M694V, M694I, K695R, V726A, A744S, R761H, E148Q) by a reverse hybridization assay (FMF StripAssay,Vienna lab,Vienna, Austria). Results. 12 patients with idiopathic uveitis were enrolled in this study. 10 of them were female. The youngest patient was a 7-year-old child and the oldest was 57. The most common complaints of patients were blurred vision and then eye redness. One patient was heterozygous for R761H. Genetic analysis of the 12 most common MEFV mutations in the patients with idiopathic uveitis didnot have any positive results. Conclusion. According to the analysis of the 12 most common MEFV gene mutations, FMF is not an underlying cause of idiopathic uveitis. On the other hand, uveitis merely could not be the first presentation of FMF.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :فرهاد صالح زاده
Additional Information:Abstracting and Indexing: PubMed , PubMed Central , Scopus , Chemical Abstracts Service (CAS) , CINAHL Plus with Full Text , Directory of Open Access Journals (DOAJ) , EBSCO Discovery Service , EBSCOhost Connection , EMBASE , Expanded Academic ASAP , Genetics Abstracts , Google Scholar Health and Wellness Resource Center , Health Reference Center Academic , HINARI Access to Research in Health Programme , J-Gate Portal , Nucleic Acids Abstracts
کلیدواژه ها (انگلیسی):Familial Mediterranean Fever ,FMF, Idiopathic Uveitis , PAN
Subjects:QW Microbiology and Immunology
WS Pediatrics
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
ID Code:5415
Deposited By: MS Soghra Golmaghani
Deposited On:12 Dec 1392 10:50
Last Modified:12 Dec 1392 10:50

Repository Staff Only: item control page

Document Downloads

More statistics for this item...