انالاپریل از طریق فعالیت آنتی اکسیدانی ادم ایسکمیک مغزی را کاهش داده و از سد خونی - مغزی محافطت می کند

پناهپور, حمداله and دهقان, غلامعباس and بهلولی, شهاب (1392) انالاپریل از طریق فعالیت آنتی اکسیدانی ادم ایسکمیک مغزی را کاهش داده و از سد خونی - مغزی محافطت می کند. Clinical and Experimental Pharmacology and Physiology ــ 41 (3). pp. 220-226. شاپا 1440-1681

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Enalapril attenuates ischaemic brain oedema and protects the blood-brain barrier in rats via an anti-oxidant action.

English Abstract

In the present study, we investigated the effects of post-ischaemic angiotensin-converting enzyme (ACE) inhibition with enalapril on vasogenic oedema formation and blood-brain barrier (BBB) integrity following transient focal cerebral ischaemia in rats.Cerebral ischaemia was induced by 60 min occlusion of the right middle cerebral artery, followed by 24 h reperfusion. Vehicle and non-hypotensive dose of enalapril (0.03 mg/kg) were administered at the beginning of the reperfusion period. A neurological deficit score (NDS) was determined for all rats at the end of the reperfusion period. Then, brain oedema formation was investigated using the wet-dry weight method and BBB permeability was evaluated on the basis of extravasation of Evans blue (EB) dye. In addition, oxidative stress was assessed by measuring reduced glutathione (GSH) and malondialdehyde (MDA) in brain homogenates. Inhibition of ACE by enalapril significantly reduced NDS and decreased brain oedema formation (P < 0.05 for both). Disruption of the BBB following ischaemia resulted in considerable leakage of EB dye into the brain parenchyma of the ipsilateral hemispheres of vehicle-treated animals. Enalapril significantly (P < 0.05) decreased EB extravasation into the lesioned hemisphere. Enalapril also augmented anti-oxidant activity in ischaemic brain tissue by increasing GSH concentrations and significantly (P < 0.05) attenuating the increased MDA levels in response to ischaemia. In conclusion, inhibition of ACE with a non-hypotensive dose of enalapril may protect BBB function and attenuate oedema formation via anti-oxidant actions. This article is protected by copyright. All rights reserved.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :حمداله پناهپور
نویسنده :غلامعباس دهقان
نویسنده :شهاب بهلولی
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کلیدواژه ها (انگلیسی):blood-brain barrier, brain oedema, enalapril, glutathione, malondialdehyde
Subjects:QT physiology
QV pharmacology
WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Pharmacology
Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:5465
Deposited By: Dr Hamdollah Panahpour
Deposited On:09 Jan 1393 08:01
Last Modified:04 Jun 1395 06:06

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