تاثیر آتورواستاتین در بیماران مبتلا به بیماری انسدادی مزمن ریه ناشی از گاز سولفور موستارد : یک کارآزمائی بالینی

قبادی مراللو, حسن and محمدزاده لاری, شهرزاد and پورفرضی, فرهاد and محمودپور, افسون and قانعی, مصطفی (1392) تاثیر آتورواستاتین در بیماران مبتلا به بیماری انسدادی مزمن ریه ناشی از گاز سولفور موستارد : یک کارآزمائی بالینی. Journal of Research in Medical Sciences ــ 19 (2). pp. 99-105. شاپا 1735-1995

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Official URL: http://jrms.mui.ac.ir/index.php/jrms/article/view/...


The effects of atorvastatin on mustard gas exposed patients with chronic obstructive pulmonary disease: A randomized controlled trail.

English Abstract

Background: Statins have anti-inflammatory effects in patients with chronic obstructive pulmonary disease (COPD). This study designed to evaluate the effects of atorvastatin on serum highly sensitive C-reactive protein (hs-CRP) and pulmonary function in sulfur mustard exposed patients with COPD. Materials and Methods: Fifty patients with chronic obstructive pulmonary disease due to sulfur mustard and high serum hs-CRP entered in this study. Participants were randomized to receive 40 mg atorvastatin or placebo in a double-blind clinical trial. Forty-five patients completed the study (n = 23 atorvastatin and n = 22 placebo). Pulse oximetry (SpO2), pulmonary function test (PFT), and 6 min walk distance test (6MWD) was measured. COPD assessment test (CAT) and St.George’s respiratory questionnaire (SGRQ) were also completed by patients at the beginning of trial and after 9 weeks of prescription of 40 mg/day atorvastatin or placebo. At fourth week, SpO2, PFT, and 6MWD were again measured. After 9 weeks serum hs-CRP was re-measured. Results: There was no significant difference between atorvastatin and the placebo group in SpO2, FEV1, and 6MWD after fourth week (P = 0.79, P = 0.12, P = 0.12, respectively). The difference between baseline and ninth week was calculated for two groups of trial and control in term of serum hs-CRP, SpO2, FEV1, and 6MWD. Significant improvement was not observed between two groups in above mentioned variables (P = 0.35, P = 0.28, P = 0.94, P = 0.43, respectively). However, the quality of life was improved by administration of atorvastatin using the CAT score (P < 0.001) and SGRQ total score (P = 0.004). Conclusion: Atorvastatin does not alter serum hs-CRP and lung functions but may improve quality of life in SM-injured patients with COPD.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :حسن قبادی مراللو
نویسنده مسئول :شهرزاد محمدزاده لاری
نویسنده :فرهاد پورفرضی
نویسنده :افسون محمودپور
نویسنده :مصطفی قانعی
Additional Information:Impact Factor: 0.684 Indexing in : ISI , PubMed , Scopus , Chemical abstract
Uncontrolled Keywords:آتورواستاتین, سولفور موستارد, COPD, hs-CRP
کلیدواژه ها (انگلیسی):Atorvastatin, COPD, hs-CRP, sulfur mustard
Subjects:QV pharmacology
W Health professions
WF Respiratory System
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:5471
Deposited By: Dr Hassan Ghobadi
Deposited On:18 Dec 1392 14:18
Last Modified:12 Nov 1393 10:11

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