ارزیابی عملکرد کلیوی در بیماران مبتلا به تب مدیترانه ای فامیلیال مطالعه ای در اردبیل

بشردوست, بهمن and ملکی, نصراله (1393) ارزیابی عملکرد کلیوی در بیماران مبتلا به تب مدیترانه ای فامیلیال مطالعه ای در اردبیل. Internal Medicine Journal ــ 44 (11). pp. 1128-1133. شاپا 1445-5994

Text - Published Version
[img] Text - Published Version
محدود به Repository staff only


Official URL: http://onlinelibrary.wiley.com/doi/10.1111/imj.125...


Assessment of renal involvement in patients with familial Mediterranean fever: a clinical study from Ardabil, Iran

English Abstract

Background And Objective Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent episodes of painful inflammation in the abdomen, chest, or joints. The association between FMF and non-amyloid glomerulopathies are unusual. In this study, we describe our experiences and observations about renal involvement in patients with FMF. Materials And Methods A total of 108 patients with FMF were enrolled in the study. Twelve patients with FMF were referred to the Nephrology Service, for evaluation and assessment of the degree of renal involvement. All the 12 patients underwent percutaneous ultrasound-guided renal biopsies and genetic analysis. Results On microscopic examination of the kidney specimens, six patients were found to have amyloidosis, five focal segmental glomerulosclerosis (FSGS), and one patient membranoproliferative glomerulonephritis (MPGN). It seems that in patients with FMF and renal amyloidosis, the response to treatment with colchicine is excellent, but in patients with FMF and FSGS, the response to treatment with colchicine is poor. We present an evidence-based algorithm, constructed based on literature review, to aid decision-making in management of renal involvement in patients with FMF. Conclusion The results of our study suggest that in patients with FMF and renal involvement, non-amyloid renal lesions should be considered in the differential diagnosis in addition to amyloidosis

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :بهمن بشردوست
نویسنده مسئول :نصراله ملکی
Additional Information:Impact Factor: 1.699 Abstracting and Indexing Information : Science Citation Index (Thomson Reuters) , Science Citation Index Expanded (Thomson Reuters), SCOPUS (Elsevier) , PubMed Dietary Supplement Subset (NLM) , Abstracts in Anthropology (Baywood Publishing) , Abstracts in Social Gerontology (EBSCO Publishing) , Abstracts on Hygiene & Communicable Diseases (CABI) , Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Academic Search Premier (EBSCO Publishing) BIOBASE: Current Awareness in Biological Sciences (Elsevier) , Biological Abstracts (Thomson Reuters) CAB Abstracts® (CABI) , CABDirect (CABI) , CAS: Chemical Abstracts Service (ACS)
کلیدواژه ها (انگلیسی):Familial Mediterranean fever ; renal involvement ; amyloidosis
Subjects:WB Practice of Medicine
WJ Urogenital System
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:5835
Deposited By: Dr Shahram Habibzadeh
Deposited On:17 Aug 1393 05:43
Last Modified:17 Aug 1393 05:43

Repository Staff Only: item control page

Document Downloads

More statistics for this item...