ارزیابی عملکرد کلیوی در بیماران مبتلا به تب مدیترانه ای فامیلیال مطالعه ای در اردبیل

Title

Assessment of renal involvement in patients with familial Mediterranean fever: a clinical study from Ardabil, Iran

English Abstract

Background And Objective Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent episodes of painful inflammation in the abdomen, chest, or joints. The association between FMF and non-amyloid glomerulopathies are unusual. In this study, we describe our experiences and observations about renal involvement in patients with FMF. Materials And Methods A total of 108 patients with FMF were enrolled in the study. Twelve patients with FMF were referred to the Nephrology Service, for evaluation and assessment of the degree of renal involvement. All the 12 patients underwent percutaneous ultrasound-guided renal biopsies and genetic analysis. Results On microscopic examination of the kidney specimens, six patients were found to have amyloidosis, five focal segmental glomerulosclerosis (FSGS), and one patient membranoproliferative glomerulonephritis (MPGN). It seems that in patients with FMF and renal amyloidosis, the response to treatment with colchicine is excellent, but in patients with FMF and FSGS, the response to treatment with colchicine is poor. We present an evidence-based algorithm, constructed based on literature review, to aid decision-making in management of renal involvement in patients with FMF. Conclusion The results of our study suggest that in patients with FMF and renal involvement, non-amyloid renal lesions should be considered in the differential diagnosis in addition to amyloidosis

Document Downloads