هادی زاده, شهرام and نجف زاده, نوروز and مأذنی, محمد and امانی, مجتبی and منصوری ترشیزی, حسن and نیاپور, علی (1393) اثرات سیتوتوکسیک کمپلکس های جدید پالادیومی دی اتیل دی تیوکربومات روی رده های سلولی سرطانی دستگاه گوارش. Biochemistry Research International ــ 2014 (2014). pp. 1-9. شاپا 2090-2247
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Official URL: http://www.hindawi.com/journals/bri/2014/813457
Title
Cytotoxic Effects of Newly Synthesized Palladium(II) Complexes of Diethyldithiocarbamate on Gastrointestinal Cancer Cell Lines
English Abstract
As a part of a drug development program to discover novel therapeutic and more effective palladium (Pd) based anticancer drugs, a series of water-soluble Pd complexes have been synthesized by interaction between [Pd (phen)(H2O)2(NO3)2] and alkylenebisdithiocarbamate(al-bis-dtc) disodium salts. This study was undertaken to examine the possible cytotoxic effect of three novel complexes (0.125–64 µg/mL) on human gastric carcinoma (AGS), esophageal squamous cell carcinoma (Kyse-30), and hepatocellular carcinoma (HepG2) cell lines. The cytotoxicity was examined using cell proliferation and acridine orange/ethidium bromide (AO/EB) assay. In order to examine the effects of new Pd(II) complexes on cell cycle status, we performed cell cycle analysis. The complexes were found to have completely lethal effects on the cell lines, and the half maximal inhibitory concentration (IC50) values obtained for the cell lines were much lower in comparison with cisplatin. We demonstrated that the three new Pd(II) complexes are able to induce G2/M phase arrest in AGS and HepG2; in addition, the Pd(II) complexes caused an S phase arrest in Kyse-30 cell line. Our results indicate that newly synthesized Pd(II) complexes may provide a novel class of chemopreventive compounds for anticancer therapy.
| Item Type: | Article |
|---|---|
| زبان سند : | انگلیسی |
| نویسنده اول : | شهرام هادی زاده |
| نویسنده مسئول : | نوروز نجف زاده |
| نویسنده : | محمد مأذنی |
| نویسنده : | مجتبی امانی |
| نویسنده : | حسن منصوری ترشیزی |
| نویسنده : | علی نیاپور |
| Additional Information: | Indexing in : PubMed , PubMed Central , Biological Sciences , Chemical Abstracts Service (CAS) , ChemSpider , CNKI Scholar , Current Abstracts , Directory of Open Access Journals (DOAJ) EBSCO Discovery Service , EBSCO MainFile , EBSCOhost Connection , Expanded Academic ASAP , Expanded Academic Index , Google Scholar , HINARI Access to Research in Health Programme , InfoTrac Custom journals , J-Gate Portal |
| کلیدواژه ها (انگلیسی): | palladium complexes , cytotoxic effects , gastrointestinal cancer , cell cycle arrest |
| Subjects: | QV pharmacology > QV 744 Medicinal Chemistry QU Biochemistry QV pharmacology QZ Pathology WI Digestive System |
| Divisions: | Faculty of Medicine > Department of Basic Sciences > Department of Biophysics Faculty of Medicine > Department of Basic Sciences > Department of Biochemistry Faculty of Medicine > Department of Basic Sciences > Department of Anatomy |
| ID Code: | 5868 |
| Deposited By: | Dr Nowruz Najafzadeh |
| Deposited On: | 11 May 1393 07:00 |
| Last Modified: | 10 Feb 1394 04:54 |
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