افزایش بیان بواسطه آدنوویروس، ژن Nrf2 در سلولهای بنیادی مزانشیمی، رتها را در برابر آسیب حاد کلیوی محافظت نمود

محمدزاده وردین, محمد and حبیبی رودکنار, مهریار and جهانیان نجف آبادی, علی (1393) افزایش بیان بواسطه آدنوویروس، ژن Nrf2 در سلولهای بنیادی مزانشیمی، رتها را در برابر آسیب حاد کلیوی محافظت نمود. Advanced Pharmaceutical Bulletin ــ 5 (2). pp. 201-208. شاپا 5881-2228

Text - Published Version

Official URL: http://journals.tbzmed.ac.ir/APB/Abstract/APB_1615...


Adenovirus-mediated over-expression of Nrf2 within mesenchymal stem cells (MSCs) protected rats against acute kidney injury

English Abstract

Purpose: Recent developments in the field of cell therapy have led to a renewed interest in treatment of acute kidney injury (AKI). However, the early death of transplanted mesenchymal stem cells (MSCs) in stressful microenvironment of a recipient tissue is a major problem with this kind of treatment. The objective of this study was to determine whether overexpression of a cytoprotective factor, nuclear factor erythroid-2 related factor 2 (Nrf2), in MSCs could protect rats against AKI. Methods: The Nrf2 was overexpressed in MSCs by recombinant adenoviruses, and the MSCs were implanted to rats suffering from cisplatin-induced AKI. Results: The obtained results showed that transplantation with the engineered MSCs ameliorates cisplatin-induced AKI. Morphologic features of the investigated kidneys showed that transplantation with the MSCs in which Nrf2 had been overexpressed significantly improved the complications of AKI. Conclusion: These findings suggested that the engineered MSCs might be a good candidate to be further evaluated in clinical trials. However, detailed studies must be performed to investigate the possible carcinogenic effect of Nrf2 overexpression.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :محمد محمدزاده وردین
نویسنده مسئول :مهریار حبیبی رودکنار
نویسنده :علی جهانیان نجف آبادی
Additional Information:Indexed in: PubMed(PMC),Scopus, Google scholar, Embase, DOAJ ,ISC
کلیدواژه ها (انگلیسی):NF-E2-Related Factor 2(Nrf2), Mesenchymal Stromal Cells(MSCs), Acute Kidney Injury, Cisplatin
Subjects:QT physiology
QU Biochemistry
QV pharmacology
QZ Pathology
WJ Urogenital System
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Anatomy
ID Code:5869
Deposited By: Dr Mohammad Mohammadzadeh
Deposited On:17 May 1394 05:40
Last Modified:18 Sep 1399 12:01

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