آیا مصرف اسید لیپوئیک روی سایتوکاین بیماران مبتلا به ام اس تاثیر می گذارد ؟

خلیلی, محمد and عظیمی, امیررضا and ایزدی, وجیهه and اقتصادی, شهریار and میرشفیعی, عباس and شهر آیین, محمدعلی and متولیان, علباس and نوروزی, عباس and صنوبر, میثم and اسکندری, غزاله and فرهودی, مهدی and امانی, فیروز (1393) آیا مصرف اسید لیپوئیک روی سایتوکاین بیماران مبتلا به ام اس تاثیر می گذارد ؟. Neuroimmunomodulation ــ 21 (6). pp. 291-296. شاپا 1423-0216

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Does Lipoic Acid Consumption Affect the Cytokine Profile in Multiple Sclerosis Patients: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

English Abstract

BACKGROUND: A limited amount of data exists regarding the effect of lipoic acid (LA), an oral antioxidant supplement, on cytokine profiles among multiple sclerosis (MS) patients. OBJECTIVE: We aimed to assess the effect of daily consumption of LA on the cytokine profiles in MS patients. METHODS: In this double-blind, placebo-controlled, randomized clinical trial, 52 relapsing-remitting MS patients with an age range of 18-50 years were recruited into 2 groups: LA consumption (1,200 mg/day) or placebo. Patients followed their prescribed supplements for 12 weeks. Fasting blood samples for cytokine profile measurement were collected at baseline and after the intervention. Anthropometric parameters were measured based on the standard guidelines. RESULTS: INF-γ, ICAM-1, TGF-β and IL-4 were significantly reduced in the LA group compared to the placebo group [(INF-γ: 0.82 ± 0.2 vs. 0.2 ± 0.2 pg/ml, p < 0.0001), (ICAM-1: 20.2 ± 9.4 vs. 8 ± 10 ng/ml, p = 0.0001), (TGF-β: 103.1 ± 20.2 vs. 54.9 ± 26 ng/ml, p < 0.0001) and (IL-4: 0.1 ± 0.1 vs. 1.02 ± 1.7 ng/ml, p = 0.0112)]. No significant changes in TNF-α, IL-6, EDSS and MMP-9 were found between the LA and placebo groups (p = 0.6, p = 0.8, p = 0.09 and p = 0.8, respectively). CONCLUSION: The results suggested that consumption of 1,200 mg LA per day beneficially affects several inflammatory cytokines including INF-γ, ICAM-1 TGF-β and IL-4. Further investigations are needed to verify the beneficial role of LA on other cytokine profiles among MS patients. © 2014 S. Karger AG, Basel.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :محمد خلیلی
نویسنده مسئول :شهریار اقتصادی
نویسنده :فیروز امانی
Additional Information:Indexing in: Pubmed/MEDLINE, Excerpta Medica, Neuroscience Citation Index.
کلیدواژه ها (انگلیسی):Lipoic acid , Multiple sclerosis , Cytokine profile , Inflammatory factors
Subjects:WD Nutrition Disease and metabolic diseases
WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Vital Statistics
ID Code:5914
Deposited By: Dr Firouz Amani
Deposited On:10 Jun 1393 06:27
Last Modified:10 Jun 1393 06:27

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