ارزیابی سیستم دارورسانی با پایه لیپیدی (فیتوسولو) برروی فراهمی زیستی خوراکی دیبودیپین

کیهانفر, فریبرز and خانی, سمیرا and بهلولی, شهاب (1393) ارزیابی سیستم دارورسانی با پایه لیپیدی (فیتوسولو) برروی فراهمی زیستی خوراکی دیبودیپین. Iranian Journal of Pharmaceutical Research ــ 13 (4). pp. 1149-1156. شاپا 1735-0328

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Official URL: http://ijpr.sbmu.ac.ir/article_1582_68.html


Evaluation of Lipid-based Drug Delivery System (Phytosolve) on Oral Bioavailability of Dibudipine

English Abstract

The objective of present study was to evaluate pharmacokinetic parameters of dibudipine Phytosolve after oral administration in rats. The solubility test was carried out to select suitable oily solvent for dibudipine. Phytosolve formulation was prepared with a medium chain triglyceride (MCT) oil (20%), soybean phospholipids (5%) and a 70% fructose solution (75%). The effect of polyol content on the mean globule size of Phytosolve formulation was studied. The optimized formulation was evaluated for robustness toward dilution, transparency, droplet size, zeta potential and transmission electron microscopic analysis. The Phytosolve of dibudipine with an average droplet size of 142.3±4.3 nm and surface charge -18.36±0.37 mv was administered orally to rats. The average relative bioavalabilities of dibudipine in the plasma with Phytosolve were 170.4% and 211.2% as compared to the oily solution and aqueous suspension respectively. So this formulation could be offered as a useful technique to improve the oral delivery of the poorly water soluble drugs such as dibudipine.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :فریبرز کیهانفر
نویسنده مسئول :سمیرا خانی
نویسنده :شهاب بهلولی
Additional Information:IF: 0.54 Indexing in: PubMed / Chemical Abstracts / Index Copernicus / IMEMR / DOAJ / Biosis Previews / ISI Web of Science (Science Citation Index Expanded) / Journal Citation Reports / IPA / EMBASE / Scopus / EMR medex / EMRO / Iran medex / Open J-Gate / Scientific Information Database (SID) / EBSCO / ISC / Iran Journal / Google Scholar.
Uncontrolled Keywords:دیبودیپین، فیتوسولو، فراهمی زیستی، حلالیت، پایه چربی
کلیدواژه ها (انگلیسی):Dibudipine; Phytosolve; Bioavailability; Solubility; Lipid-based for
Subjects:QV pharmacology > QV 704 Pharmaceutics
QV pharmacology
Divisions:School of Pharmacy > Department of Pharmacology
ID Code:5961
Deposited By: Dr Shahab Bohlooli
Deposited On:06 Jul 1393 04:07
Last Modified:18 Sep 1393 08:57

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