تالیدوماید آسیب کلیوی ناشی از سیس پلاتین را در مدل حیوانی کاهش می دهد

امیرشاهرخی, کیوان and خلیلی, علیرضا (1394) تالیدوماید آسیب کلیوی ناشی از سیس پلاتین را در مدل حیوانی کاهش می دهد. Inflammation ــ 38 (2). pp. 476-484. شاپا 0360-3997

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Official URL: http://link.springer.com/article/10.1007%2Fs10753-...


Thalidomide Ameliorates Cisplatin-Induced Nephrotoxicity by Inhibiting Renal Inflammation in an Experimental Model

English Abstract

Cisplatin is a platinum-based chemotherapy drug. However, its chemotherapeutic use is restricted by serious side effects, especially nephrotoxicity. Inflammatory mechanisms have a significant role in the pathogenesis of cisplatin-induced nephrotoxicity. Thalidomide is an immunomodulatory and anti-inflammatory agent and is used for the treatment of various inflammatory diseases. The purpose of this study was to investigate the potential nephroprotective effect of thalidomide in a mouse model of cisplatin-induced nephrotoxicity. Nephrotoxicity was induced in mice by a single injection of cisplatin (15 mg/kg, i.p.), and treated with thalidomide (50 and 100 mg/kg/day, orally) for four days, beginning 24 hours prior to the cisplatin injection. Renal toxicity induced by cisplatin was demonstrated by increasing plasma levels of creatinine and blood urea nitrogen (BUN). Cisplatin increased the renal production of proinflammatory cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and transforming growth factor (TGF)-β1. In addition, kidney levels of malondialdehyde (MDA), myeloperoxidase (MPO) and nitric oxide (NO) were increased by cisplatin. Biochemical results showed that thalidomide reduced cisplatin-induced increase in plasma creatinine and BUN. Thalidomide treatment also significantly reduced tissue levels of the proinflammatory cytokines, MDA, MPO, and NO and increased anti-inflammatory cytokine IL-10. Furthermore, Histological examination indicated that thalidomide ameliorated renal damage caused by cisplatin. These data suggest that thalidomide attenuates cisplatin-induced nephrotoxicity possibly by inhibition of inflammatory reactions. Taken together, our findings indicate that thalidomide might be a valuable candidate for prevention of nephrotoxicity in patients receiving cisplatin.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :کیوان امیرشاهرخی
نویسنده :علیرضا خلیلی
Additional Information:IF: 2.208 Indexed in: ISI, PubMed/Medline, Scopus, Embase
کلیدواژه ها (انگلیسی):cisplatin; nephrotoxicity; thalidomide; cytokines; nitric oxide
Subjects:QV pharmacology
WJ Urogenital System
Divisions:School of Pharmacy > Department of Pharmacology
ID Code:6005
Deposited By: Dr Kivan Amir Shahrikhi
Deposited On:29 Jan 1394 03:53
Last Modified:03 May 1400 09:22

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