تهیه و ارزیابی نانوذرات پلیمری کراس لینک شده و نشده حاوی داروی دوکسوروبیسین

شکری, نرگس and اکبری جور, حمید and فولاددل, شمیله and خلج, علی and دیناروند, رسول and عزیزی, ابراهیم (1390) تهیه و ارزیابی نانوذرات پلیمری کراس لینک شده و نشده حاوی داروی دوکسوروبیسین. African journal of pharmacy and pharmacology ــ 5 (7). pp. 797-805. شاپا 1996-0816

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Official URL: http://www.academicjournals.org/journal/AJPP/editi...


Preparation and characterization of poly(caprolactone fumarate) nanoparticles (PCLF NPs)and crosslinked PCLF NPs as carriers for doxorubicin HCl

English Abstract

Polycaprolactone fumarate (PCLF) is a biocompatible and biodegradable polyester which has been evaluated for tissue engineering. Hydrophobic PCLF nanoparticles (NPs) may be uptaken by reticule endotelial system rich organs and useful for treatment of related tumors. NPs of three PCLFs were produced through nanoprecipitation method. Crosslinked (CR) NPs were prepared using Benzyl peroxide (BPO) and N-vinyl pyrrolidone (NVP) under heating. Doxorubicin HCl (Dox) loaded NPs of PCLF530, 1250 and 2000 showed size of 149, 238 and 274 nm, respectively and zeta potential of about -40 mV, while their drug loadings (DL%) were 2.1, 6.0 and 6.8%, respectively. Dox was released from the NPs in 2 to 4 days in phosphate buffer saline, pH 7.4 at 37°C. Crosslinking of NPs could be completed at BPO/PCLF of 0.01 and NVP/PCLF of 0.1 at 40°C with no change in NP size. PCLF530 NPs possessed a higher CR% than two other NPs. The CR% was reduced in formulations without NVP and with NVP/PCLF of 0.8. Electron microscopic images revealed spherical (CR and not CR) NPs and core-shell structure. PCLF1250 NPs showed both more DL% and smaller size in relation to NPs of PCLF530 and 2000, respectively with a prolonged drug release profile and can be useful as a passive targeted drug delivery system. PCLF NPs could be CR (64.3%) through chemical crosslinking and consequently higher DL% (11.6%), longer drug release (6 days) and smaller size (188 nm) than not CR NPs.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :نرگس شکری
نویسنده مسئول :حمید اکبری جور
سایر :شمیله فولاددل
سایر :علی خلج
سایر :رسول دیناروند
سایر :ابراهیم عزیزی
Additional Information:indexed in: Chemical Abstract ,ABC Chemistry , African Index Medicus , Animal Science Database , Biofuels Abstracts , Botanical Pesticides , CAB Abstracts , CABI's Environmental Impact , Crop Physiology Abstracts , Crop Science Database , Dairy Science Abstracts , DOAJ , EVISA EZB , Field Crop Abstracts , Forest Products Abstracts ,Forest Science Database , Forestry Abstracts , Google Scholar , Grasslands and Forage Abstracts , Helminthological Abstracts Horticultural Science Abstracts Irrigation and Drainage Abstracts Leisure Recreation and Tourism Abstracts Maize Abstracts Medbio World Nematological Abstracts
کلیدواژه ها (انگلیسی):Crosslinked nanoparticles; Crosslinked percent; N-vinyl pyrrolidone; nanoparticle size, release profile
Subjects:QV pharmacology > QV 704 Pharmaceutics
Divisions:School of Pharmacy > Department of Pharmaceutics
ID Code:6025
Deposited By: Dr Narges Shokri
Deposited On:26 Aug 1393 04:52
Last Modified:26 Aug 1393 05:37

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