بررسی اثر درمانی پروپرانولول در کودکان زیر 15 سال مبتلا به همانژیوم

Title

Assessment of Propranolol efficacy on pediatric haemangioma

English Abstract

Introduction : Hemangiomas are the most common vascular tumor in infancy. Systemic cortons are the first choice of treatment although they have many side effects. Recent studies show Propranolol efficacy on hemangiomas treatment. It has rapid effect and few side effects. These reasons make us to review its effect. Materials and methods : This interventional study was done on 20 children refer to Bu-Ali hospital. Treatment indications were multiple hemangiomas, organ malfunction and enlarging hemangioma. Treatment on those was started by 1mg/kg/day and increased to 3 mg/kg/day and continued for 6 month. After treatment completion 6 month follow up was done. Results : Patients mean age was 23.15 ± 11.24 month. 65% of them were female and 35% was male. Mean size of lesion was 4.85 ± 3.26 Cm. 70% patients had acceptable respond (more than 50% decrease in size) and 30% had partial respond (less than 50%). This effect is similar to corton effect (about 84%) but with less side effects. In this study there is significant relation between mean lesion size decrease and propranolol usage but no significant relation between size of lesion, age, sex and regression. Conclusion: This study shows that Propranolol has acceptable effect on hemangiomas regression and could be suggested as first choice of hemangimas treatment.

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