فعالسازی سیستم ایمنی رفتارهای مرتبط با افسردگی را بصورت مجزا در مراحل ابتدایی و تاخیری شکل گیری مغز پس از تولد در موش کوچک آزمایشگاهی تغییر می دهد.

مجیدی ذوالبنین, جعفر and دوستی, محمد حسین and برادران, بهزاد and امانی, محمد and آذرفرین, مریم and سالاری, علی اکبر (1393) فعالسازی سیستم ایمنی رفتارهای مرتبط با افسردگی را بصورت مجزا در مراحل ابتدایی و تاخیری شکل گیری مغز پس از تولد در موش کوچک آزمایشگاهی تغییر می دهد. Neuroimmunology and Neuroinflammation ــ 1 (1). pp. 35-39. شاپا 2347-8659

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Neonatal immune activation during early and late postnatal brain development differently influences depression-related behaviors in adolescent and adult C57BL/6 mice

English Abstract

Immune challenge during early and late neonatal periods can induce robust alterations in physiological and behavioral functions, resulting in greater risk for the development of neuropsychiatric disorders, such as anxiety and depression, later in life. In addition, previous studies concluded that increasing age correlates with increased depression behaviors in humans and rodents. This study aimed to investigate for the first time whether immune challenge with a viral mimic, synthetic double-stranded ribonucleic acid (Poly I: C) during different neonatal periods can differently affect depression-related behaviors in adolescent and adult mice. Methods: Male C57BL/6 mice were treated with either saline or Poly I:C (1 mg/kg and 4 mg/kg) on postnatal days (PND) 3-5 (early neonatal phase) or PND 14-16 (late neonatal phase), and then subjected to behavioral tests, including tail suspension test and forced swimming test, during adolescence (PND 35 or 40) and adulthood (PND 85 or 90). Results: The results demonstrated that early neonatal immune activation increases depression-related behaviors in both adolescent and adult mice, but late neonatal immune activation only increases depression in adult mice. In other words, these findings indicated that the nature of the offspring's neuropathology can depend on the severity of the insult, the pup's age at the time of the insult, and offspring age at the time of behavioral testing. Conclusion: These findings suggest that dose and timing of neonatal insult and offspring age may be important factors for evaluating neuropsychiatric disorders in adults who experienced early life infection.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :جعفر مجیدی ذوالبنین
نویسنده :محمد حسین دوستی
نویسنده :بهزاد برادران
نویسنده :محمد امانی
نویسنده :مریم آذرفرین
نویسنده مسئول :علی اکبر سالاری
کلیدواژه ها (انگلیسی):Age , depression , hypothalamic-pituitary-adrenal axis , mice , neonatal infection , Poly I:C
Subjects:QT physiology
WM Psychiatry
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:6050
Deposited By: Dr Mohammad Amani
Deposited On:17 Aug 1393 04:57
Last Modified:17 Aug 1393 04:57

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