ورزش قبل به طور منظم مانع از اختلال شکل پذیری سیناپسی در رتهای ماده محروم از خواب می شود.

سعادتی, حکیمه and شیبانی, وحید and اسماعیلی ماهانی, سعید and حاج علی, وحید and مظاهری, شهرزاد (1393) ورزش قبل به طور منظم مانع از اختلال شکل پذیری سیناپسی در رتهای ماده محروم از خواب می شود. brain research bulletin ــ 108 (2014). pp. 100-105. شاپا 0361-9230

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Prior regular exercise prevents synaptic plasticity impairment in sleep deprived female rats

English Abstract

Previous studies have indicated that physical exercise plays a preventive role in synaptic plasticity deficits in the hippocampus of sleep-deprived male rats. The objective of the present study was to evaluate the effects of treadmill running on early long term potentiation (E-LTP) at the Cornu Ammonis (CA1) area of the hippocampus in sleep-deprived female rats. Intact and ovariectomiezed (OVX) female Wistar rats were used in the present study. The exercise protocol was four weeks treadmill running and the multiple platform method was applied to induce 72 h sleep deprivation (SD). We examine the effect of exercise and/or SD on synaptic plasticity using in vivo extracellular recording in the CA1 area of the hippocampus. The field excitatory post-synaptic potential (fEPSP) slope was measured before and 2 h after high frequency stimulation (HFS) in the experimental groups. Field potential recording indicated that the induction and maintenance phase of E-LTP impaired in the sleep deprived animals compared to the other groups. After 72 h SD, E-LTP impairments were prevented by 4 weeks of regular treadmill exercise. In conclusion, the synaptic plasticity deficit in sleep-deprived female rats was improved by regular physical exercise. Further studies are suggested to evaluate the possible underlying mechanisms.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :حکیمه سعادتی
نویسنده مسئول :وحید شیبانی
Additional Information:IF:2.974 Abstracting and Indexing : ISI, Scopus, PubMed, Embase
کلیدواژه ها (انگلیسی):Sleep deprivation; Long term potentiation; Physical exercise; Female rat
Subjects:QT physiology
WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:6051
Deposited By: Dr. Hakimeh Saadati
Deposited On:29 Sep 1393 04:24
Last Modified:18 Sep 1399 13:18

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