زینک اکساید و نانوذرات زینک اکساید به عنوان تسهیل کننده جذب فرآورده های موضعی دارویی و آرایشی بهداشتی

شکری, نرگس and گودرزی, محمدتقی and اکبری جور, حمید and سلطانی, یاسمن (1393) زینک اکساید و نانوذرات زینک اکساید به عنوان تسهیل کننده جذب فرآورده های موضعی دارویی و آرایشی بهداشتی. Journal of pharmaceutical research ــ 13 (2). pp. 40-44. شاپا 0973-7200

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Zinc Oxide and Zinc Oxide nanoparticles as enhancers in topical pharmaceutical and cosmetic products

English Abstract

Objectives: Scientists have widely investigated the use of chemical enhancers to improve drug transport through the skin. In this study, ZnO and ZnO nanoparticles (ZnO-NPs) has been used as dermal absorption enhancers for Ibuprofen (IP). Methods: Seven different formulations containing IP, ZnO, or ZnO-NPs were prepared. Dermal absorption experiments were performed at 32°C using a diffusion cell containing phosphate buffer saline (pH 7.4) and a slice of chicken skin. Cumulative amounts of skin permeated IP, ZnO or ZnO-NPs were plotted over time. Results: After 60 minutes, 90, 8 and 81 mg ZnO, ZnO-NPs and IP were passed through the skin, respectively. This amount for IP was 105, 114, 131 and 183 mg in presence of 100 mg ZnO, 100 mg ZnO-NPs, 200 mg ZnO-NPs, and 500 mg ZnO-NPs, respectively. Maximum amount of not-permeated IP was seen for formulation 1 (IP without enhancer) and minimum not-permeated IP was seen for formulation 5 (IP with 500 mg ZnO-NPs as enhancer). Conclusion: ZnO and more strongly ZnO-NPs could act as enhancers for transdermal delivery of IP. Such effect was improved by increase in concentration of ZnO-NPs. Therefore, ZnO-NPs can be used as enhancer in dermal drug delivery formulations.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :نرگس شکری
نویسنده :محمدتقی گودرزی
نویسنده :حمید اکبری جور
نویسنده :یاسمن سلطانی
Additional Information:Indexing In index Copernicus, chemical abstract:
Uncontrolled Keywords:زینک اکساید، نانوذرات زینک اکساید، ایبوپروفن، عبور پوستی
کلیدواژه ها (انگلیسی):Zinc Oxide, Zinc Oxide nanoparticles, Ibuprofen, Enhancer, skin permeation
Subjects:QV pharmacology > QV 704 Pharmaceutics
QV pharmacology
Divisions:School of Pharmacy > Department of Pharmaceutics
ID Code:6084
Deposited By: Dr Narges Shokri
Deposited On:16 Sep 1393 05:56
Last Modified:01 Sep 1394 08:24

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