اثر حلال های آبدوست بر روی تسهیل دارورسانی پوستی آلبومین

شکری, نرگس and اکبری جور, حمید and خلج, علی (1393) اثر حلال های آبدوست بر روی تسهیل دارورسانی پوستی آلبومین. International Journal of Pharmaceutical Sciences and Research ــ 5 (8). pp. 3175-3182. شاپا 2320-5148

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Official URL: http://ijpsr.com/bft-article/effect-of-hydrophilic...


Effect of hydrophilic solvents on enhancing transdermal delivery of albumin

English Abstract

Objectives: Transdermal drug delivery suggests several advantages and has been vastly investigated over last decades. Chemical enhancers improve the quantity of drug penetration through the skin. In this study, hydrophilic solvents have been used as enhancers to promote dermal penetration of albumin. Methods: 20 different formulations containing albumin and hydrophilic solvents were prepared. Transdermal absorption experiments for each formulation were performed using a diffusion cell and a slice of chicken skin as model at 32°C for 3 hours. Samples from the medium were withdrawn and analyzed for albumin concentration. Cumulative amounts of albumin were plotted for each formulation. Results: After 3 hours, 6.8, 5.8, 69.0, 7.9, 11.1, 25.2, 32.0, 98.0, 21.3 and 74.3 mg of albumin were passed through the skin, using formulations containing deionized water (DW), acetic acid, ethyl acetate (EA), methanol, ethanol, 2-propanol, isopropyl alcohol (IPA), glycerol, ethylene glycol (EG) and propylene glycol (PG), respectively. Conclusion: PG, EA and glycerol could act as enhancers for transdermal delivery of albumin. Such delivery was increased using 4 mL of them instead of 2 mL and using exposure time of 3 hours instead of 1.5 hours. The most effective enhancer was found glycerol, showing a maximum albumin permeation of 98.0 mg. Therefore, the study suggested using glycerol as enhancer for transdermal delivery of albumin or other similar proteins in cosmeceutical products.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :نرگس شکری
نویسنده :حمید اکبری جور
نویسنده :علی خلج
Uncontrolled Keywords:آلبومین، نفوذ پوستی، تسریع کننده عبور، حلال های آبدوست
کلیدواژه ها (انگلیسی):Albumin, Skin permeation, Enhancer, Hydropilic solvents
Subjects:QV pharmacology > QV 704 Pharmaceutics
Divisions:School of Pharmacy > Department of Pharmaceutics
ID Code:6092
Deposited By: Dr Narges Shokri
Deposited On:27 Aug 1393 09:56
Last Modified:01 Sep 1394 08:21

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