تاثیرات درازمدت کورتیزول بر میزان رشد و تکثیر سلولهای بنیادی \ پیش ساز عصبی در شرایط آزمایشگاهی

عبدانی پور, علیرضا and سقا, محسن and نوری زاده, علی and پاکزاد, ایرج and الطریحی, تقی (1393) تاثیرات درازمدت کورتیزول بر میزان رشد و تکثیر سلولهای بنیادی \ پیش ساز عصبی در شرایط آزمایشگاهی. Neurological Research ــ 37 (2). pp. 117-124. شاپا 0161-6412

Text - Published Version
[img] Text - Published Version
محدود به Repository staff only


Official URL: http://www.maneyonline.com/doi/abs/10.1179/1743132...


In vitro study of the long-term cortisol treatment effects on the growth rate and proliferation of the neural stem/precursor cells.

English Abstract

Adult neural stem/precursor cells (NSPCs) residing in the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus of the hippocampus are involved in the memory formations and psychological problems. It is believed that basal levels of glucocorticoids are essential for neuronal development, plasticity, and survival, while stress-mediated levels of glucocorticoids produce neuronal loss. Degeneration of NSPCs by the apoptotic and necrotic stimuli have great devastating outcomes on the brain and contributes to the pathophysiology of neurological as well as psychological disorders. Using MTT assay, acridine orange, and TUNEL assay, we have demonstrated that cortisol at high and excessive (more than 5 μM) levels had anti-proliferative effects on the NSPCs derived from subventricular and subgranular zones in a dose- and time-dependent manner through apoptosis as well as necrosis. These outcomes can highlight the role of stress-mediated decline of adult neurogenesis in the aging brain and interconnect stress-mediated cortisol secretion with brain aging diseases.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :علیرضا عبدانی پور
نویسنده مسئول :محسن سقا
نویسنده :علی نوری زاده
نویسنده :ایرج پاکزاد
نویسنده :تقی الطریحی
Additional Information:Abstracting & Indexing : MEDLINE , PubMed , Scopus , Neurological Research is included in the following services: Current Awareness in Neurosciences , Current Contents - Clinical Medicine , Current Contents - Life Sciences , Elsevier BIOBASE/Current Awareness in Biological Sciences (CABS) , EMBASE/Excerpta Medica , Research Alert® , Science Citation Index
کلیدواژه ها (انگلیسی):Adult neurogenesis,; Cortisol,; Dentate gyrus,; NSPCs,; Neurosphere; Subventricular zone,
Subjects:QS Human Anatomy
QT physiology
WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Anatomy
ID Code:6124
Deposited By: Dr Mohsen Sagha
Deposited On:19 Sep 1393 10:08
Last Modified:13 Oct 1393 03:59

Repository Staff Only: item control page

Document Downloads

More statistics for this item...