همراهی سندرم دی جورج با رماتیسم ایدیوپاتیک نوجوانان

عنوان انگليسی

Association of juvenile idiopathic arthritis and digeorge syndrome; a case report

خلاصه انگلیسی

Juvenile idiopathic arthritis (JIA) belongs to a group of arthritis with unknown etiology that occurs in children under 16 years old. Pathogenesis of this disease proposes the role of autoimmune process which is induced by antigens and results in inflammation of synovials and cartilage[1]. DiGeorge syndrome (DGS) or velo-cardio-facialsyndrome (VCFS) is a genetic disorder due to a defect in 22q11.2 chromosome[2]. Patients with 22q11.2 DS usually have characteristic facies including retrognathia or micrognathia, long face, downturned mouth, short philtrum low-set, malformed ears and hypertelorism. Congenital heart defects, either a cleft palate or incompetence of the soft palate, and immune deficiencies are common. Patients may have short stature and occasional instances of growth hormone

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