ورزش قبلی منظم اثرات کاهشی محرومیت از خواب بر سطح عامل نوروتروفیک مشتق از مغز را در هیپوکامپ رتهای ماده فاقد تخمدان محروم از خواب را معکوس می کند.

سعادتی, حکیمه and شیبانی, وحید and اسماعیلی ماهانی, سعید and درویش زاده ماهانی, فاطمه and مظاهری, شهرزاد (1393) ورزش قبلی منظم اثرات کاهشی محرومیت از خواب بر سطح عامل نوروتروفیک مشتق از مغز را در هیپوکامپ رتهای ماده فاقد تخمدان محروم از خواب را معکوس می کند. Regulatory peptides ــ 194-95 (2014). pp. 11-15. شاپا 0167-0115

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Prior regular exercise reverses the decreased effects of sleep deprivation on brain-derived neurotrophic factor levels in the hippocampus of ovariectomized female rats

English Abstract

Previous studies indicated that brain-derived neurotrophic factor (BDNF) is the main candidate to mediate the beneficial effects of exercise on cognitive function in sleep deprived male rats. In addition, our previous findings demonstrate that female rats are more vulnerable to the deleterious effects of sleep deprivation on cognitive performance and synaptic plasticity. Therefore, the current study was designed to investigate the effects of treadmill exercise and/or sleep deprivation (SD) on the levels of BDNF mRNA and protein in the hippocampus of female rats. Intact and ovariectomized (OVX) female Wistar rats were used in the present experiment. The exercise protocol was four weeks treadmill running and sleep deprivation was accomplished using the multiple platform method. Quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) and immunoblot analysis were used to evaluate the level of BDNF mRNA and protein in the rat hippocampus respectively. Our results showed that protein and mRNA expression of BDNF was significantly (p < 0.05) decreased after 72 h SD in OVX rats in compared with other groups. Furthermore, sleep deprived OVX rats under exercise conditions had a significant (p < 0.05) up-regulation of the BDNF protein and mRNA in the hippocampus. These findings suggest that regular exercise can exert a protective effect against hippocampus-related functions and impairments induced by sleep deprivation probably by inducing BDNF expression.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :حکیمه سعادتی
نویسنده مسئول :وحید شیبانی
نویسنده :سعید اسماعیلی ماهانی
نویسنده :فاطمه درویش زاده ماهانی
نویسنده :شهرزاد مظاهری
Additional Information:IF:2.014 Indexing in: ISI
کلیدواژه ها (انگلیسی):Sleep deprivation; Brain derived neurotrophic factors; Physical exercise; Female rat
Subjects:QT physiology
WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:6181
Deposited By: Dr. Hakimeh Saadati
Deposited On:29 Sep 1393 09:30
Last Modified:18 Sep 1399 13:15

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