کندسارتان ادم ایسکمیک مغزی را کاهش داده و از سد خونی - مغزی در برابر آسیب ایسکمیک - ریپرفیوژن در موش صحرایی محافظت می کند.

پناهپور, حمداله and نکوئیان, علی اکبر and دهقان, غلامعباس (1393) کندسارتان ادم ایسکمیک مغزی را کاهش داده و از سد خونی - مغزی در برابر آسیب ایسکمیک - ریپرفیوژن در موش صحرایی محافظت می کند. Iranian Biomedical Journal ــ 18 (4). pp. 232-238. شاپا 1028-852X

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Official URL: http://ibj.pasteur.ac.ir/browse.php?a_id=1168&sid=...


Candesartan Attenuates Ischemic Brain Edema and Protects the Blood–Brain Barrier Integrity from Ischemia/Reperfusion Injury in Rats

English Abstract

Background: Angiotensin II (Ang II) has an important role on cerebral microcirculation; however, its direct roles in terms of ischemic brain edema need to be clarified. This study evaluated the role of central Ang II by using candesartan, as an AT1 receptor blocker, in the brain edema formation and blood-brain barrier (BBB) disruption caused by ischemia/reperfusion (I/R) injuries in rat. Methods: Rats were exposed to 60-min middle cerebral artery (MCA) occlusion. Vehicle and non-hypotensive doses of candesartan (0.1 mg/kg) were administered one hour before ischemia. Neurological dysfunction scoring was evaluated following 24 h of reperfusion. Animals were then decapitated under deep anesthesia for the assessments of cerebral infarct size, edema formation, and BBB permeability. Results: The outcomes of 24 h reperfusion after 60-min MCA occlusion were severe neurological disability, massive BBB disruption (Evans blue extravasation = 12.5 ± 1.94 µg/g tissue), 4.02% edema, and cerebral infarction (317 ± 21 mm3). Candesartan at a dose of 0.1 mg/kg, without changing arterial blood pressure, improved neurological dysfunction scoring together with significant reductions in BBB disruption (54.9%), edema (59.2%), and cerebral infarction (54.9%). Conclusions: Inactivation of central AT1 receptors, if not accompanied with arterial hypotension, protected cerebral micro-vasculatures from damaging effects of acute stroke..

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :حمداله پناهپور
Additional Information:indexing in: PubMed/MEDLINE, PubMed Central (PMC), BIOSIS Previewsو Index Medicus, CINAHL, BIOBASE, Scopus, Google Scholar, Chemical Abstracts, Index Copernicus, CAB Abstracts, Cambridge Scientific Abstracts, CINAHL Plus, EMBASE/Excerpta Medica, VCU Library, Directory of Open Access Journals (DOAJ), Index Medicus for the WHO Eastern Mediteranean Region (IMEMR), Islamic World ience Islamic World Science Citation Database (ISC)
کلیدواژه ها (انگلیسی):Blood–brain barrier , Brain edema , AT1 receptor , Candesartan
Subjects:QT physiology
QV pharmacology
WG Cardiovascular System
WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:6195
Deposited By: Dr Hamdollah Panahpour
Deposited On:03 Oct 1393 04:00
Last Modified:03 Oct 1393 04:00

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