مهار گیرنده های AT1 مرکزی آنژیوتانسین دو مغز را در برابر آسیب ایسکمیک - ریپرفیوژن در موش صحرایی با فشار خون طبیعی محافظت می کند

پناهپور, حمداله and نکوئیان, علی اکبر and دهقان, غلامعباس (1393) مهار گیرنده های AT1 مرکزی آنژیوتانسین دو مغز را در برابر آسیب ایسکمیک - ریپرفیوژن در موش صحرایی با فشار خون طبیعی محافظت می کند. Iranian Journal of Medical Sciences ــ 39 (6). pp. 536-542. شاپا 0253-0716

Text - Published Version

Official URL: http://ijms.sums.ac.ir/index.php/IJMS/article/view...


Blockade of Central Angiotensin II AT1 Receptor Protects the Brain from Ischemia/Reperfusion Injury in Normotensive Rats

English Abstract

Background: Stroke is the third leading cause of invalidism and death in industrialized countries. There are conflicting reports about the effects of Angiotensin II on ischemia-reperfusion brain injuries and most data have come from chronic hypertensive rats. In this study, hypotensive and non-hypotensive doses of candesartan were used to investigate the effects of angiotensin II AT1 receptor blockade by transient focal cerebral ischemia in normotensive rats. Methods: In this experimental study, 48 male Sprague-Dawley rats were randomly divided into four groups (n=12). Sham group, the control ischemic group, and two ischemic groups received candesartan at doses of 0.1 or 0.5 mg/kg at one hour before ischemia. Transient focal cerebral ischemia was induced by 60 minutes occlusion of the middle cerebral artery, followed by 24 h reperfusion. The neurological deficit score was evaluated at the end of the reperfusion period. The total cortical and striatal infarct volumes were determined using triphenyltetrazolium chloride staining technique. Tissue swelling was calculated for the investigation of ischemic brain edema formation. Results: In comparison with the control ischemic group, AT1 receptor blockade with both doses of candesartan (0.1 or 0.5 mg/kg) significantly improved neurological deficit and lowered cortical and striatal infarct sizes. In addition, pretreatment with candesartan significantly reduced ischemia induced tissue swelling. Conclusion: Angiotensin II by stimulating AT1 receptors, participates in ischemia-reperfusion injuries and edema formation. AT1 receptor blockade with candesartan decreased ischemic brain injury and edema and improved neurological outcome.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :حمداله پناهپور
Additional Information:Indexed in: PubMed , EMBASE , Scopus , CINAHL , EBSCO , Academic Search Complete , CAB , ProQuest , DOAJ , Index Medicus for the WHO Eastern Mediterranean Region , Index Copernicus , ISC , Google Scholar , Open J-Gate , Socolar Geneva Free Med. J , Electronic Journals Librry Free Medical Journals(Amedeo) , Academic Journals Database ,
کلیدواژه ها (انگلیسی):Angiotensin II , Angiotensin AT1 receptor , Candesartan , Stroke , Rat
Subjects:QT physiology
QV pharmacology
WG Cardiovascular System
WL Nervous system
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of physiology
ID Code:6196
Deposited By: Dr Hamdollah Panahpour
Deposited On:03 Oct 1393 04:09
Last Modified:03 Oct 1393 04:09

Repository Staff Only: item control page

Document Downloads

More statistics for this item...