بیان بین از حد آنزیمهای پردازشگر microRNA دروشا و دایسر در دیابت ملیتوس بارداری

رحیمی, گیتی and جعفری, ناصر and خدابخش, مهنوش and شیرزاد, زهره and پیری دوگاهه, هادی (1393) بیان بین از حد آنزیمهای پردازشگر microRNA دروشا و دایسر در دیابت ملیتوس بارداری. Gynecological Endocrinology ــ 31 (2). pp. 156-159. شاپا 0951-3590

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Official URL: http://informahealthcare.com/doi/abs/10.3109/09513...


Upregulation of microRNA Processing Enzymes Drosha and Dicer in Gestational Diabetes Mellitus

English Abstract

MicroRNAs (miRNAs) have been shown to play important roles in diverse cellular processes and linked to variety of disorders. Dicer and Drosha are two major enzymes in the miRNA biogenesis process. DGCR8 is the assistant of Drosha in the microprocessor complex. In this study, we evaluated the mRNA expression profiles of major miRNA processing machinery Drosha, Dicer, and DGCR8 in gestational diabetes mellitus (GDM), pregnant and healthy women. Our findings indicate that the expression levels of Drosha, Dicer and DGCR8 were upregulated in both pregnant and GDM patients compared to the control group. However, Drosha and Dicer were upregulated more than pregnant group. In conclusion, we detected dysregulation of Drosha, Dicer and DGCR8 expression in pregnant and GDM patients when compared to healthy control participants. Therefore, we favor the hypothesis that miRNAs are involved in the development of GDM.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :گیتی رحیمی
نویسنده :ناصر جعفری
نویسنده :مهنوش خدابخش
نویسنده :زهره شیرزاد
نویسنده مسئول :هادی پیری دوگاهه
Additional Information:Impact Factor: 1.136 Indexing in: Science Citation Index Expanded , PubMed: , Index Medicus/MEDLINE; BIOBASE/Current Awareness in Biological Sciences (CABS); Current Contents and EMBASE (Excerpta Medica).
کلیدواژه ها (انگلیسی):DGCR8; Dicer; Drosha; Gestational Diabetes Mellitus; microRNA; pregnancy
Subjects:QZ Pathology
WD Nutrition Disease and metabolic diseases
WQ Obstetrics
Divisions:Faculty of Medicine > Department of Anesthesiology , Obstetrics & Gynecology
Faculty of Medicine > Department of Basic Sciences > Department of Microbiology
ID Code:6229
Deposited By: MS Soghra Golmaghani
Deposited On:13 Nov 1393 04:20
Last Modified:24 Mar 1397 11:36

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