title

استرس اکسیداتیو و مهار کولین استراز در بزاق و پلاسما متعاقب تماس تحت مزمن با مالاتیون در موش صحرایی

عبدالهی, محمد and مصطفی لو, سارا and پورنورمحمدی, شیرین and شادنیا, شاهین (1382) استرس اکسیداتیو و مهار کولین استراز در بزاق و پلاسما متعاقب تماس تحت مزمن با مالاتیون در موش صحرایی. Comparative Biochemistry & Physiology Part C Toxicology & Pharmacology ــ 137 (1). pp. 29-34. شاپا 1532-0456

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Title

Oxidative stress and cholinesterase inhibition in saliva and plasma of rats following subchronic exposure to malathion

English Abstract

The aim of this study was to examine whether malathion, a commonly used organophosphate (OP), might induce oxidative stress and cholinesterase (ChE) depression in saliva and plasma in rats following subchronic exposure mimicking human exposure. Malathion was administered orally at doses of 100, 500 and 1500 ppm for 4 weeks. Oxidative stress was determined by measuring the malondialdehyde concentration, the end product of lipid peroxidation, and assessing total antioxidant power. Four weeks oral administration of malathion at doses of 100 ppm, 500 ppm and 1500 ppm depressed plasma ChE activity to 45% (P<0.01), 48% (P<0.01) and 41% (P<0.01) of control, respectively. Malathion at doses of 100 ppm, 500 ppm and 1500 ppm depressed saliva ChE activity to 73% (P<0.01), 75% (P<0.01) and 78% (P<0.01) of control, respectively. Malathion at doses of 100 ppm, 500 ppm and 1500 ppm increased plasma antioxidant power by 33% (P<0.01), 59% (P<0.01) and 118% (P<0.01) of control, respectively. Malathion did not change saliva antioxidant power. Malathion at doses of 100 ppm, 500 ppm and 1500 ppm increased plasma thiobarbituric acid reactive substances (TBARS) by 61% (P<0.01), 69% (P<0.01) and 63% (P<0.01) of control, respectively. Malathion at doses of 500 ppm and 1500 ppm increased saliva TBARS by 19% (P<0.01) and 22% (P<0.01) of control, respectively. Malathion (100 ppm) did not change saliva TBARS level. We concluded that in OP subchronic exposure, depression of ChE is accompanied by induction of oxidative stress that might be beneficial in monitoring OP toxicity.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :محمد عبدالهی
نویسنده :سارا مصطفی لو
نویسنده :شیرین پورنورمحمدی
نویسنده :شاهین شادنیا
Additional Information:Impact Factor: 2.829 Abstracting and Indexing: Science Citation Index , Science Citation Index Expanded , BIOSIS Previews , MEDLINE , PubMed , Index medicus , Scopus , Aqualine Abstracts , Current Contents/ASCA , Current Contents/BIOMED Database , Current Contents/Life Sciences , Current Contents/SciSearch Database , EMBASE , Reference Update , EMBiology , Zoological Record
Uncontrolled Keywords:ارگانوفسفره، استرس اکسیداتیو، کولین استراز، بزاق
کلیدواژه ها (انگلیسی):organophophate, oxidative stress, cholinesterase, saliva
Subjects:QV pharmacology > QV 600 Toxicology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:6245
Deposited By: Dr Sara Mostafalou
Deposited On:15 Oct 1393 05:16
Last Modified:15 Oct 1393 05:16

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