عدم تاثیر آلوپورینول در کاهش استرس اکسیداتیو در بیماران دیابتی: آزمون بالینی دوسویه کور

افشاری, مژگان and لاریجانی, باقر and رضایی, علی and مجتهدی, علیرضا and زمانی, محمد جعفر and آستانه ای, فاطمه and مصطفی لو, سارا and حسین نژاد, آرش and حشمت, رامین and عبداللهی, محمد (1383) عدم تاثیر آلوپورینول در کاهش استرس اکسیداتیو در بیماران دیابتی: آزمون بالینی دوسویه کور. Biomedicine & Pharmacotherapy ــ 58 (10). pp. 546-550. شاپا 0753-3322

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Ineffectiveness of allopurinol in reduction of oxidative stress in diabetic patients; a randomized, double-blind placebo-controlled clinical trial

English Abstract

The objective of this randomized, double-blind placebo-controlled clinical trial was to evaluate the value of allopurinol treatment on reduction of oxidative stress in patients with diabetes type II patients. Forty-one diabetic type II subjects were randomly assigned to two groups. One group (n = 20) received 100 mg allopurinol three times a day for 14 days and the other group (n = 21) received a placebo. Blood and saliva samples were collected before and after intervention for analysis of lipid peroxidation level and total antioxidant power as indices of oxidative stress. At the beginning of the study, the groups were similar based upon age, duration of diabetes, fasting glucose, and HbA1c. Both allopurinol and placebo were effective in reduction of lipid peroxidation and total antioxidant power whether in saliva or plasma in a similar extent. HbA1c and FBS levels did not change through the study neither in case or placebo group. It is concluded that allopurinol therapy is not more effective than placebo in reduction of oxidative stress in diabetic patients. The same trend of changes in blood and saliva shown for oxidative stress indices was interesting and suggests a chance for saliva to be valuable in diagnosis of oxidative stress. However, to elaborate the exact role of allopurinol in diabetes, further large randomized clinical trials are needed.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :مژگان افشاری
نویسنده :سارا مصطفی لو
نویسنده مسئول :محمد عبداللهی
Additional Information:Impact factor: 2.069 Indexing in : Science Citation Index , Science Citation Index Expanded , Current Contents - Life Sciences , BIOSIS Previews , MEDLINE, PubMed Index medicus , Elsevier BIOBASE Scopus , Pascal/INIST-CNRS , SCISEARCH , ScienceDirect , BIOSIS/Biological Abstracts , EMBASE/Excerpta Medica ,
Uncontrolled Keywords:آلوپورینول، استرس اکسیداتیو، دیابت
کلیدواژه ها (انگلیسی):allopurinol, oxidative stress, diabetes
Subjects:QV pharmacology
WK Endocrine System
Divisions:School of Pharmacy > Department of Toxicology
ID Code:6246
Deposited By: Dr Sara Mostafalou
Deposited On:15 Oct 1393 05:30
Last Modified:24 Mar 1397 12:17

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