مطالعه مقایسه ای پایدارسازی کورکومین با آلبومین سرم گاوی : چشم اندازی بر کاربرد در انتقال دارو

نادی, محمدمصطفوی and اشرفی کوشک, محمدرضا and منصوری, کامران and قدمی, سید ابوالقاسم and امانی, مجتبی and قبادی, سیروس and خدارحمی, رضا (1393) مطالعه مقایسه ای پایدارسازی کورکومین با آلبومین سرم گاوی : چشم اندازی بر کاربرد در انتقال دارو. International Journal of Food Properties ــ 18 (3). pp. 638-659. شاپا 1532-2386

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Official URL: http://www.tandfonline.com/doi/abs/10.1080/1094291...


Comparative spectroscopic studies on Curcumin Stabilization by Association to Bovine Serum Albumin and Casein: A perspective on drug-delivery application

English Abstract

Curcumin is a natural polyphenolic compound with anticancer, anti-inflammatory, and antioxidation properties. Low water solubility and rapid hydrolytic degradation are two challenges limiting use of curcumin. In this study, the role of the native/modified forms of bovine serum albumin and casein, as food-grade biopolymers and safe drug delivery systems and also protein chemical modification in stabilizing of curcumin were surveyed. Investigation on curcumin stability indicated that curcumin binding to the native bovine serum albumin is stronger than the modified bovine serum albumin, and hence, native protein could suppress water-mediated curcumin degradation. Drug competitive binding, fluorescence resonance energy transfer, and molecular docking studies suggested that the binding site for curcumin has not been changed upon albumin modification. Moreover, different observations were made for both the native and modified caseins. It appears from thermodynamic analyses that in “protein-curcumin” systems, water molecules are excluded from the vicinity of curcumin, so that some of them may provide novel tools to increase both food quality and the bioavailability of curcumin as a health promoting agent.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :محمدمصطفوی نادی
نویسنده :محمدرضا اشرفی کوشک
نویسنده :مجتبی امانی
نویسنده مسئول :رضا خدارحمی
Additional Information:2012 Impact Factor: 0.906 abstracted and/or Indexed in: Science Citation Index Expanded (SCIE), and Social Sciences Citation Index, Index Medicus/MEDLINE, Aquatic Sciences and Fisheries Abstracts, BioSciences Information Service of Biological Abstracts (BIOSIS), Chemical Abstracts, Chemoreception Abstracts, Current Contents, Current Contents/Agriculture, Biology, and Environmental Sciences, Engineering Index/COMPENDEX PLUS, Foods Adlibra, Food Science and Technology Abstracts, ISI Alerting Services, PubSCIENCE
کلیدواژه ها (انگلیسی):Curcumin, Bovine serum albumin, Casein, Chemical modification, Hydrolytic degradation, Anti-cancer activity
Subjects:QU Biochemistry
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Biophysics
ID Code:6258
Deposited By: Dr Mojtaba Amani
Deposited On:30 Oct 1393 08:50
Last Modified:25 Nov 1393 08:32

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