ان-استیل سیستئین، یک درمان جدید برای مسمویت حاد با ترکیبان ارگانوفسفره

شادنیا, شاهین and اشرافی وند, سپیده and مصطفی لو, سارا and عبدالهی, محمد (1390) ان-استیل سیستئین، یک درمان جدید برای مسمویت حاد با ترکیبان ارگانوفسفره. International journal of pharmacology ــ 7 (6). pp. 732-735. شاپا 1811-7775

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Official URL: http://scialert.net/fulltext/?doi=ijp.2011.732.735...


N-acetylcysteine a novel treatment for acute human organophosphate poisoning

English Abstract

Since oxidative stress markers are increased in Organophosphates (OPs) toxicity, the efficacy of the antioxidant N-acetyl-L-cysteine (NAC) as an adjunct therapy to atropine and pralidoxime for acute OPs toxicity was evaluated. Twenty-four adult subjects with acute OP toxicity were included in a randomized single blind controlled trial on the use of intravenous NAC. Among included subjects, twelve were randomized to receive NAC and the rest did not receive NAC. The results showed that the needing to atropine but not pralidoxime was reduced in NAC group. The duration of hospitalization was reduced in the NAC group. Addition of NAC to current treatment protocol of acute OPs poisoning is recommended.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :شاهین شادنیا
نویسنده :سارا مصطفی لو
نویسنده مسئول :محمد عبدالهی
Additional Information:IF=1.503 Indexed In : Science Citation Index Expanded , BIOSIS Previews, Science Citation Index (EXP) , SCIMAGO , SCOPUS ASCI-Database , CABI , Chemical Abstract Services , Directory of Open Access Journals , EMBASE , Google Scholar , ISI Web of Knowledge ,
Uncontrolled Keywords:Organophosphate, N-acetyl-L-cysteine, poisoning
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:6264
Deposited By: Dr Sara Mostafalou
Deposited On:02 Nov 1393 04:55
Last Modified:02 Nov 1393 04:55

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