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شواهد بیوشیمیایی دال بر پتانسیل ترکیبات ارگانوفسفره در تغییر متابولیسم کبدی گلوکز به سمت مقاومت به انسولین از طریق مسیرهای التهابی و استرس اکسیداتیو

مصطفی لو, سارا and اقبال, محمد علی and نیلی احمدآبادی, امیر and بعیری, مریم and عبدالهی, محمد (1391) شواهد بیوشیمیایی دال بر پتانسیل ترکیبات ارگانوفسفره در تغییر متابولیسم کبدی گلوکز به سمت مقاومت به انسولین از طریق مسیرهای التهابی و استرس اکسیداتیو. Toxicology and industrial health ــ 28 (9). pp. 840-851. شاپا 0748-2337

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Title

Biochemical evidence on the potential role of organophosphates in hepatic glucose metabolism toward insulin resistance through inflammatory signaling and free radical pathways

English Abstract

Several studies show that organophosphate pesticides exert several effects on glucose homeostasis. The current study investigates the influence of subchronic exposure to malathion (MT) on hepatic gluconeogenesis in relation to acetyl cholinesterase (AChE) inhibition, oxidative stress and inflammatory response in the rat. MT was administered by gavage at doses of 25, 50 and 100 mg/kg for 32 days. Fasting hyperglycemia was seen in line with an increased activity of hepatic phosphoenolpyruvate carboxykinase, glucose 6-phosphatase and tumor necrosis factor α. In addition to the impaired glucose tolerance and inhibition of AChE in a dose-dependent manner, there were significant increases in hepatic lipid peroxidation, carbonyl groups and 8-deoxyguanosine as the biomarkers of reactive oxygen species-mediated damage to lipid, protein and DNA, respectively. Altered quality of the liver in glucose production especially gluconeogenesis could be a compensatory mechanism against MT toxicity or even result in tissue damage. MT-induced insulin resistance in the liver occurs through oxidative and inflammatory signaling pathways.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :سارا مصطفی لو
نویسنده مسئول :محمد عبدالهی
Additional Information:IF=1.710
کلیدواژه ها (انگلیسی):Organophosphate, inflammation, glucose metabolism, oxidative stress, malathion
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:6265
Deposited By: Dr Sara Mostafalou
Deposited On:02 Nov 1393 05:03
Last Modified:31 Jan 1394 07:48

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