اثر مهاری متیل سولفونیل متان بر بیان ژنهای مربوط به هیپر تروفی بطنی

محمدی, پرهام سعداله and گرجانی, علیرضا and نجفی, مسلم and حمزه ای, حسین and مالکی دیزجی, نسرین and امیدی, یداله and فائزی, شبنم and دارابی, مسعود and مصطفی لو, سارا and حسن زاده, کامبیز and خانی, سجاد (1391) اثر مهاری متیل سولفونیل متان بر بیان ژنهای مربوط به هیپر تروفی بطنی. International journal of pharmacology ــ 8 (7). pp. 638-646. شاپا 1811-7775

Text - Published Version

Official URL: http://scialert.net/abstract/?doi=ijp.2012.647.651


Inhibitory Effects of Methylsulfonylmethane on Ventricular Hypertrophy Related Gene Expression

English Abstract

Methylsulfonylmethane (MSM) is naturally accruing organic sulphur that is known as a potent anti-inflammatory compound. The aim of this study was to investigate the effect of MSM on mRNA expressions of angiotensinogen, endothelin-1 (ET-1) and Transforming Growth Factor (TGF)-β1 in rats with monocrotaline (MCT)-induced pulmonary arterial hypertension. Wistar rats were randomly assigned to 38-days pretreatment or 28-days treatment. MSM was administered to either 10 days before or 14 days after a single dose of MCT. Right Ventricle (RV) tissue samples were obtained to evaluate changes in the inflammatory genes expression using RT-PCR assay. The expression levels of angiotensinogen, ET-1 and TGF-β1 significantly were reduced (p<0.01) at efficient dose of MSM in MCT-induced pulmonary arterial hypertensive rats. Results suggest that harmful effects of MCT induced PAH on the RV function could be attenuated by anti-inflammatory actions through the suppression of local RAAS along with associated growth-promoting factors TGF-β1 and ET-1.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :پرهام سعداله محمدی
نویسنده مسئول :علیرضا گرجانی
نویسنده :سارا مصطفی لو
Additional Information:IF=1.503 Indexed In : ISI , BIOSIS Previews, Science Citation Index (EXP) , SCOPUS , CABI , Chemical Abstract Services , EMBASE , Google Scholar
کلیدواژه ها (انگلیسی):inflammation, right ventricle, monocrotaline, endothelin-1, TGF-B1, angiotensinogen
Subjects:QV pharmacology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Pharmacology
School of Pharmacy > Department of Toxicology
ID Code:6286
Deposited By: Dr Sara Mostafalou
Deposited On:05 Nov 1393 09:47
Last Modified:21 Feb 1399 20:03

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