تراکم استخوانی در بیماران مبتلا به صرع با قابلیت حرکت

یقینی, امید and تنکابنی, سید حسن and شاه کرمی, سید محمدامیر and احمدآبادی, فرزاد and شریعتمداری, فخرالدین and عبداله گرجی, فاطمه (1393) تراکم استخوانی در بیماران مبتلا به صرع با قابلیت حرکت. The Indian Journal of Pediatrics ــ 82 (3). pp. 225-229. شاپا 0019-5456

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Official URL: http://link.springer.com/article/10.1007%2Fs12098-...


Bone Mineral Density in Ambulatory Children with Epilepsy

English Abstract

OBJECTIVE: To elucidate the effects of antiepileptic drugs (AEDs) on bone health status of ambulatory epileptic children. METHODS: A total of 120 epileptic children aged 2-15 y were enrolled in three groups. The first group was on therapy with carbamazepine, phenobarbital or primidone. The second was treated with valproic acid and the third group was untreated. Serum calcium, phosphorous, total alkaline phosphatase, and parathyroid hormone levels were compared between groups. Bone mineral density tests were also performed at four sites of the lumbar spine and three sites of femoral neck and results were compared between the groups. RESULTS: Of all enrolled subjects, 67 patients (55.8 %) were vitamin D deficient. The three groups were not significantly different in terms of vitamin D, calcium, phosphorus, total alkaline phosphatase, and parathyroid hormone levels. While patients in first group had lower Z-score of femoral neck and lumbar spine compared to those on valproic acid, these values were also significantly different than that of the third group. CONCLUSIONS: It can be concluded that both enzyme-inducing AEDs and non enzyme-inducing AEDs decrease bone mineral density (BMD). Also alkaline phosphatase (ALP) is affected in ambulatory epileptic children on enzyme-inducing AEDs. Nevertheless, valproic acid (a non-enzyme-inducing agent) does not have the mentioned side effects.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :امید یقینی
نویسنده مسئول :سید حسن تنکابنی
نویسنده :سید محمدامیر شاه کرمی
نویسنده :فرزاد احمدآبادی
نویسنده :فخرالدین شریعتمداری
سایر :فاطمه عبداله گرجی
Additional Information:2013 -Impact Factor : 0.919 Indexing in: PubMed/Medline, Science Citation Index Expanded , Current Contents - Clinical Medicine , BIOSIS Previews, SCOPUS, EMBASE, Google Scholar, Academic OneFile, Expanded Academic, Health Reference Center Academic, Indian Science Abstracts, INIS Atomindex, MedInd, OCLC, PASCAL, SCImago, Summon by ProQuest,
کلیدواژه ها (انگلیسی):Antiepileptic drugs , Bone mineral density , Vitamin D , Epilepsy , Children
Subjects:WE Musculoskeletal system
WL Nervous system
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
ID Code:6321
Deposited By: Dr Farzad Ahmadabadi
Deposited On:16 Jan 1394 03:27
Last Modified:16 Jan 1394 03:27

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