نانو ذرات زینک اکساید به عنوان تسریع کننده نفوذ پوستی حلال ها و سرفکتنت ها

شکری, نرگس and اکبری جور, حمید (1393) نانو ذرات زینک اکساید به عنوان تسریع کننده نفوذ پوستی حلال ها و سرفکتنت ها. Journal of pharmaceutical research ــ 13 (3). pp. 85-91. شاپا 7200-0937

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Zinc Oxide nanoparticles as skin permeation enhancer for solvents and surfactants

English Abstract

Objectives: Transdermal route of drug administration has absorbed large interests for its many advantages. Several materials, mainly different solvents and surfactants, have been used as excipients to enhance the skin permeation of drugs. Nanoparticles (NPs) also have been proved to affect the permeations of substances. ZnO-NPs, widely used in topical products, have been investigated in this study in terms of their effects on permeations of different substances (excipients) and therefore permeations of active ingredients. Methods: To determine the skin permeation of every substance, diffusion cell method and a cut of chicken skin were employed following by quantification of the substance concentration in the receiver medium after 1.5 hours. Results: The substances showed different permeations. The ZnO-NPs increased the permeation of each substance. In the absence and also in the presence of the ZnO-NPs, the mean amounts permeated were respectively belonged to hydrophobic solvents, hydrophilic solvents, oily solvents and surfactants. The ZnO-NPs increased the permeation of hydrophobic solvents, oily solvents, hydrophilic solvents and surfactants, with 31.33, 24, 20.33 and 5.34%, respectively. Such increases, were not dependent on the molecular weight (MW) of the oily and hydrophobic solvents but were dependent on the MW of the hydrophilic solvents and the surfactants. Conclusion: The ZnO-NPs are suggested to be used for enhancing the skin permeations of solvents or surfactants in topical products which potentially can improve absorption of active ingredients. Besides, such enhancing effect of the ZnO-NPs should be noticed in topical products where they may increase drug delivery dose and also increase drug or excipient systemic toxicity.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :نرگس شکری
نویسنده :حمید اکبری جور
Additional Information:Indexing in: index Copernicus, Chemical abstract
Uncontrolled Keywords:نانوذرات زینک اکساید، حلال ها، سرفکتنت ها
کلیدواژه ها (انگلیسی):ZnO-NPs, Solvents, Surfactants
Subjects:QV pharmacology > QV 704 Pharmaceutics
QV pharmacology
Divisions:School of Pharmacy > Department of Pharmaceutics
ID Code:6374
Deposited By: Dr Narges Shokri
Deposited On:23 Dec 1393 05:46
Last Modified:01 Sep 1394 08:10

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