آفت کش ها و بیماری های مزمن انسان: شواهد، مکانیسم و چشم انداز

مصطفی لو, سارا and عبدالهی, محمد (1392) آفت کش ها و بیماری های مزمن انسان: شواهد، مکانیسم و چشم انداز. Toxicology and Applied Pharmacology ــ 268 (2). pp. 157-177. شاپا 0041-008X

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Official URL: http://www.sciencedirect.com/science/article/pii/S...


Pesticides and Human Chronic Diseases; Evidences, Mechanisms, and Perspectives

English Abstract

Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing. There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson, Alzheimer, and amyotrophic lateral sclerosis (ALS), birth defects, and reproductive disorders. There is also circumstantial evidence on the association of exposure to pesticides with some other chronic diseases like respiratory problems, particularly asthma and chronic obstructive pulmonary disease (COPD), cardiovascular disease such as atherosclerosis and coronary artery disease, chronic nephropathies, autoimmune diseases like systemic lupus erythematous and rheumatoid arthritis, chronic fatigue syndrome, and aging. The common feature of chronic disorders is a disturbance in cellular homeostasis, which can be induced via pesticides' primary action like perturbation of ion channels, enzymes, receptors, etc., or can as well be mediated via pathways other than the main mechanism. In this review, we present the highlighted evidence on the association of pesticide's exposure with the incidence of chronic diseases and introduce genetic damages, epigenetic modifications, endocrine disruption, mitochondrial dysfunction, oxidative stress, endoplasmic reticulum stress and unfolded protein response (UPR), impairment of ubiquitin proteasome system, and defective autophagy as the effective mechanisms of action.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :سارا مصطفی لو
نویسنده مسئول :محمد عبدالهی
Additional Information:Impact Factor: 3.630 Abstracting and Indexing: Science Citation Index , PubMed, MEDLINE , BIOSIS , Chemical Abstracts , International Pharmaceutical Abstracts , Medical Abstracts Newsletter , EMBASE , Research Alert , Safety Science Abstracts , Toxicology Abstracts , Current Contents (Life Sciences, Clinical Medicine) Chemical Hazards Index , Scopus , EMBiology
Uncontrolled Keywords:آفت کش، بیماری های مزمن، سمیت ژنتیک، اپی ژنتیک
کلیدواژه ها (انگلیسی):Pesticides, chronic disease, genotoxicity, epigenetics
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:6394
Deposited By: Dr Sara Mostafalou
Deposited On:04 Dec 1393 06:45
Last Modified:04 Dec 1393 06:45

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