سمیت های غیر سرطانی بنزن در ارتباط با سلامت انسان

بهادر, حاجی and مصطفی لو, سارا and عبدالهی, محمد (1392) سمیت های غیر سرطانی بنزن در ارتباط با سلامت انسان. Toxicology and Applied Pharmacology ــ 276 (2). pp. 83-94. شاپا 1096-0333

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Official URL: http://www.sciencedirect.com/science/article/pii/S...


Current understandings and perspectives on non-cancer health effects of benzene: A global concern

English Abstract

OBJECTIVE: Benzene, as a volatile organic compound, is known as one of the main air pollutants in the environment. The aim of this review is to summarize all available evidences on non-cancerous health effects of benzene providing an overview of possible association of exposure to benzene with human chronic diseases, specially, in those regions of the world where benzene concentration is being poorly monitored. METHODOLOGY: A bibliographic search of scientific databases including PubMed, Google Scholar, and Scirus was conducted with key words of "benzene toxic health effects", "environmental volatile organic compounds", "diabetes mellitus and environmental pollutants", "breast cancer and environmental pollution", "prevalence of lung cancer", and "diabetes prevalence". More than 300 peer reviewed papers were examined. Experimental and epidemiologic studies reporting health effects of benzene and volatile organic compounds were included in the study. RESULTS: Epidemiologic and experimental studies suggest that benzene exposure can lead to numerous non-cancerous health effects associated with functional aberration of vital systems in the body like reproductive, immune, nervous, endocrine, cardiovascular, and respiratory. CONCLUSION: Chronic diseases have become a health burden of global dimension with special emphasis in regions with poor monitoring over contents of benzene in petrochemicals. Benzene is a well known carcinogen of blood and its components, but the concern of benzene exposure is more than carcinogenicity of blood components and should be evaluated in both epidemiologic and experimental studies. Aspect of interactions and mechanism of toxicity in relation to human general health problems especially endocrine disturbances with particular reference to diabetes, breast and lung cancers should be followed up.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :حاجی بهادر
نویسنده :سارا مصطفی لو
نویسنده مسئول :محمد عبدالهی
Additional Information:Impact Factor: 3.630 Indexing in: MEDLINE ,Science Citation Index ,EMBASE ,Chemical Abstracts , Scopus , BIOSIS International Pharmaceutical Abstracts , Medical Abstracts Newsletter , Research Alert , Safety Science Abstracts , Toxicology Abstracts , Current Contents (Life Sciences, Clinical Medicine) , Chemical Hazards Index , EMBiology
Uncontrolled Keywords:بنزن، سمیت غیر سرطانی، دیابت، اندوکرین
کلیدواژه ها (انگلیسی):benzene, non-cancer toxicity, diabetes, endocrine
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:6491
Deposited By: Dr Sara Mostafalou
Deposited On:27 Dec 1393 04:35
Last Modified:27 Dec 1393 04:35

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