استرس اکسیداتیو و پیری

Title

Oxidative Stress in Aging

English Abstract

Constant formation of free radicals mainly reactive oxygen species (ROS) is the main characteristic of all living systems which use oxygen for their basal metabolism. Primarily, ROS are considered an integral component of basic cell regulation and signaling pathways certainly, suppressing tumor progression which forms the basis of the most chemotherapeutic and radiotherapeutic agents. The most common ROS are superoxide radical () and hydrogen peroxide (H2O2) which can stimulate consecutive reactions leading to further production of free radicals and related oxidative damage to cellular compartments. On the other side, there are several antioxidant complexes which defend cellular integrity against free radical-induced damages by neutralizing oxidative elements. Superoxide dismutase is the main antioxidant enzyme which converts to H2O2 and then the other enzyme located in peroxisomes, catalase, disposes of H2O2 by converting it to O2 and H2O. Keeping the balance of such cell homeostasis in a level at which ROS are not able to damage cells is vital. Excessive ROS not only cause damage toward cellular lipids and DNA but also participate in posttranslational dysfunction of proteins or enzymes involved in keeping viability and function of the cells

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