استرس اکسیداتیو و پیری

عبدالهی, محمد and مریدانی, مجید and اوکزی, آروما and مصطفی لو, سارا (1393) استرس اکسیداتیو و پیری. Oxidative Medicine and Cellular Longevity ــ 2014 (876834). pp. 1-2. شاپا 1942-0900

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Official URL: http://www.hindawi.com/journals/omcl/2014/876834


Oxidative Stress in Aging

English Abstract

Constant formation of free radicals mainly reactive oxygen species (ROS) is the main characteristic of all living systems which use oxygen for their basal metabolism. Primarily, ROS are considered an integral component of basic cell regulation and signaling pathways certainly, suppressing tumor progression which forms the basis of the most chemotherapeutic and radiotherapeutic agents. The most common ROS are superoxide radical () and hydrogen peroxide (H2O2) which can stimulate consecutive reactions leading to further production of free radicals and related oxidative damage to cellular compartments. On the other side, there are several antioxidant complexes which defend cellular integrity against free radical-induced damages by neutralizing oxidative elements. Superoxide dismutase is the main antioxidant enzyme which converts to H2O2 and then the other enzyme located in peroxisomes, catalase, disposes of H2O2 by converting it to O2 and H2O. Keeping the balance of such cell homeostasis in a level at which ROS are not able to damage cells is vital. Excessive ROS not only cause damage toward cellular lipids and DNA but also participate in posttranslational dysfunction of proteins or enzymes involved in keeping viability and function of the cells

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :محمد عبدالهی
نویسنده :سارا مصطفی لو
Additional Information:Impact Factor 3.363 Indexing in: Citation Index Expanded , MEDLINE , PubMed , PubMed Central , Science Scopus , EMBASE , Biological Abstracts , BIOSIS Previews , Chemical Abstracts Service (CAS) , CNKI Scholar , Directory of Open Access Journals (DOAJ) , EBSCOhost Connection , Ei Compendex , Engineering Information (Ei) , Google Scholar , HINARI Access to Research in Health Programme , Index Medicus , J-Gate Portal , Journal Citation Reports - Science Edition
Uncontrolled Keywords:استرس اکسیداتیو، پیری
کلیدواژه ها (انگلیسی):oxidative stress, ageing
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:6492
Deposited By: Dr Sara Mostafalou
Deposited On:27 Dec 1393 04:49
Last Modified:27 Dec 1393 04:49

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