اوارکتومی اثرات منفی محرومیت از خواب را در شکل پذیری سیناپسی تشدید نمی کند.

حاج علی, وحید and شیبانی, وحید and اسماعیلی ماهانی, سعید and حاج علی زاده, زهرا and شعبانی, محمد and پاسبانی علی آبادی, حمزه and سعادتی, حکیمه and اسماعیل پور, خدیجه (1394) اوارکتومی اثرات منفی محرومیت از خواب را در شکل پذیری سیناپسی تشدید نمی کند. Physiology & Behavior ــ 144 . pp. 81-73. شاپا 0031-9384

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Ovariectomy does not exacerbate the negative effects of sleep deprivation on synaptic plasticity in rats

English Abstract

In our previous work, we found that female rats showed more cognitive impairment than male rats following 72 h sleep deprivation (SD). Here, we compared the intact female with ovariectomized (OVX) rats to assess the potential modulatory effects of endogenous female sex hormones against the 48 h SD-induced cognitive and synaptic modulations. The multiple platform method was applied for SD induction and spatial performances were determined using Morris water maze (MWM) task. Early longterm potentiation (E-LTP) was evaluated in area CA1 of the hippocampus and PCR and western blotting assays were employed to assess hippocampal BDNF gene and protein expression. To reveal any influence of sleep loss on stress level, we also measured the plasma corticosterone levels of animals. Regardless of reproductive status, SD significantly impaired short-term memory and LTP, but did not significantly change the BDNF expression in the hippocampus. The corticosterone levels were decreased in both intact and OVX female rats following SD. These findings suggest that depletion of female sex steroid hormones does not lead to any heightened responsivity of female animals to the negative effects of SD on cognitive and synaptic functions.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :وحید حاج علی
نویسنده مسئول :وحید شیبانی
نویسنده :حکیمه سعادتی
Additional Information:Impact Factor(2014)2.976 Indexed in:ISI, Scopus, PubMed, Embase
کلیدواژه ها (انگلیسی):Sleep deprivation; Spatial memory; Long-term potentiation; Brain derived neurotropic factor; Ovariectomy
Subjects:WL Nervous system
Divisions:Vice Chancellor for Research and Technology > Deputy for Research and Technology management and Medical Information
ID Code:6557
Deposited By: Dr. Hakimeh Saadati
Deposited On:16 Jan 1394 04:16
Last Modified:18 Sep 1399 13:12

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