افزایش بیان NF-E2-related factor 2 در سلولهای بنیادی مزانشیمی به منظور بهبود کاردیومیوپلاستی سلولی

محمدزاده وردین, محمد and حبیبی رودکنار, مهریار (1393) افزایش بیان NF-E2-related factor 2 در سلولهای بنیادی مزانشیمی به منظور بهبود کاردیومیوپلاستی سلولی. Electronic Physician ــ 6 (2). pp. 808-813. شاپا 2008-5842

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NF-E2-related factor 2 over-expression in mesenchymal stem cells to improve cellular cardiomyoplasty

English Abstract

Myocardial infarction (MI) is the leading cause of death worldwide. Various therapeutic strategies have been introduced for MI treatment. In recent years, interest in utilizing mesenchymal stem cells (MSCs) for MI therapy has increased. In fact, the use of MSCs for MI treatment, known as cellular cardiomyoplasty, is in the clinical trial stage. However, despite promising results, most MSCs die after transplantation as a result of exposure to various stresses. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a well-known cytoprotective transcription factor, protects MSCs against some stresses. Over-expression of Nrf2 in MSCs decreases their apoptosis in vitro without any adverse effects on their differentiation capacity. Therefore, we hypothesized that over-expression of Nrf2 in MSCs can improve cellular cardiomyoplasty.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :محمد محمدزاده وردین
نویسنده مسئول :مهریار حبیبی رودکنار
Additional Information:indexing in: Pubmed central(PMC), Islamic World Science Citation Center (ISC), Index Copernicus, (DOAJ), IranMedex , Google Scholar
کلیدواژه ها (انگلیسی):NF-E2-Related Factor 2 (Nrf2); Mesenchymal Stromal Cells; Myocardial Infarction; Cardiomyoplasty
Subjects:QS Human Anatomy
QV pharmacology
QY Clinical Pathology
WG Cardiovascular System
WH Hemic and Lymphatic System
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Anatomy
ID Code:6570
Deposited By: Dr Mohammad Mohammadzadeh
Deposited On:15 Jan 1394 09:23
Last Modified:18 Sep 1399 12:03

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