بررسی مکانیسم های مولکولی دخیل در اختلال متابولیسم گلوکز توسط سرب در ارتباط با کبد و پانکراس

مصطفی لو, سارا and بعیری, مریم and بهادر, حاجی and سلطانی رضائی راد, محمد and غلامی, مهدی and عبدالهی, محمد (1393) بررسی مکانیسم های مولکولی دخیل در اختلال متابولیسم گلوکز توسط سرب در ارتباط با کبد و پانکراس. Environmental Toxicology and Pharmacology ــ 39 (1). pp. 16-26. شاپا 1382-6689

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Molecular mechanisms involved in lead induced disruption of hepatic and pancreatic glucose metabolism

English Abstract

Lead (Pb) is a toxic heavy metal known to be associated with pathology of various human chronic diseases. This study has focused on the effect of lead on glucose homeostasis with regard to metabolic function of pancreas and liver. Islets of Langerhans were isolated from the pancreas of rats and exposed to lead for 24h, then insulin release along with markers of ER stress and oxidative stress were evaluated. In another part, lead was administered to rats for 32 days and after evaluating criteria of diabetes, the activity of gluconeogenesis and glycogenolysis enzymes, and markers of oxidative stress and inflammation were measured in the liver. Lead disrupted insulin secretory function of islets through activating GSK-3β and ER stress, and increased activity of gluconeogenic enzymes in the liver featured by glucose intolerance. Chronic exposure to lead can disrupt glucose homeostasis by affecting pancreas and liver mainly through induction of insulin resistance.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :سارا مصطفی لو
نویسنده مسئول :محمد عبدالهی
Additional Information:Impact Factor: 1.862 Abstracting and Indexing: Science Citation Index , Science Citation Index Expanded , Current Contents - Life Sciences , BIOSIS Previews , Index medicus, MEDLINE , PubMed Elsevier BIOBASE , Chemical Abstracts , Current Contents/Life Sciences , EMBASE , Environmental Mutagene Information Center , Scopus , EMBiology
Uncontrolled Keywords:سرب، متابولیسم گلوکز، پانکراس، انسولین، کبد
کلیدواژه ها (انگلیسی):lead, glucose metabolism, pancreas, insulin, liver
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
WI Digestive System
Divisions:School of Pharmacy > Department of Toxicology
ID Code:6610
Deposited By: Dr Sara Mostafalou
Deposited On:31 Jan 1394 04:55
Last Modified:31 Jan 1394 04:55

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