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اثر تالیدوماید بر آسیب موکوسی معده ناشی از اتانول

امیرشاهرخی, کیوان ، خلیلی, علیرضا (1393) اثر تالیدوماید بر آسیب موکوسی معده ناشی از اتانول. Chemico-Biological Interactions ــ 225 (2015). ص.ص.63-69. شاپا 1872-7786

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عنوان انگليسی

The effect of thalidomide on ethanol-induced gastric mucosal damage in mice: Involvement of inflammatory cytokines and nitric oxide

خلاصه انگلیسی

Excessive ethanol ingestion causes gastric mucosal damage through the inflammatory and oxidative processes. The present study was aimed to evaluate the protective effect of thalidomide on ethanol-induced gastric mucosal damage in mice. The animals were pretreated with vehicle or thalidomide (30 or 60 mg/kg, orally), and one hour later, the gastric mucosal injury was induced by oral administration of acidified ethanol. The animals were euthanized one hour after ethanol ingestion, and gastric tissues were collected to biochemical analyzes. The gastric mucosal lesions were assessed by macroscopic and histopathological examinations. The results showed that treatment of mice with thalidomide prior to the administration of ethanol dose-dependently reduced the gastric ulcer index. Thalidomide pretreatment significantly reduced the levels of pro-inflammatory cytokines [tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6], malondialdehyde (MDA) and myeloperoxidase (MPO) activity. In addition, thalidomide significantly inhibited ethanol-induced nitric oxide (NO) overproduction in gastric tissue. Histological observations showed that ethanol-induced gastric mucosal damage was attenuated by thalidomide pretreatment. It seems that thalidomide as an anti-inflammatory agent may have a protective effect against alcohol-induced mucosal damage by inhibition of neutrophil infiltration and reducing the production of nitric oxide and inflammatory cytokines in gastric tissue.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده مسئول :کیوان امیرشاهرخی
نویسنده :علیرضا خلیلی
ضریب تاثیر و نمایه مجلات:IF: 2.618 Indexed in: ISI, PubMed/Medline, Scopus, Embase
کلیدواژه ها (فارسی):آسیب موکوسی معده،اتانول، تالیدوماید
کلیدواژه ها (انگلیسی):Thalidomide, Gastric mucosal damage, Ethanol , Thalidomide , Inflammation , Nitric oxide
موضوعات :QV فارماکولوژی
WI سیستم گوارشی
بخش های دانشگاهی :دانشکده داروسازی > بخش فارماکولوژی
کد شناسایی :6617
ارائه شده توسط : دکتر کیوان امیرشاهرخی
ارائه شده در تاریخ :06 اردبهشت 1394 03:30
آخرین تغییر :10 مرداد 1401 12:54

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