اثر تالیدوماید بر آسیب موکوسی معده ناشی از اتانول

امیرشاهرخی, کیوان and خلیلی, علیرضا (1393) اثر تالیدوماید بر آسیب موکوسی معده ناشی از اتانول. Chemico-Biological Interactions ــ 225 (2015). pp. 63-69. شاپا 1872-7786

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The effect of thalidomide on ethanol-induced gastric mucosal damage in mice: Involvement of inflammatory cytokines and nitric oxide

English Abstract

Excessive ethanol ingestion causes gastric mucosal damage through the inflammatory and oxidative processes. The present study was aimed to evaluate the protective effect of thalidomide on ethanol-induced gastric mucosal damage in mice. The animals were pretreated with vehicle or thalidomide (30 or 60 mg/kg, orally), and one hour later, the gastric mucosal injury was induced by oral administration of acidified ethanol. The animals were euthanized one hour after ethanol ingestion, and gastric tissues were collected to biochemical analyzes. The gastric mucosal lesions were assessed by macroscopic and histopathological examinations. The results showed that treatment of mice with thalidomide prior to the administration of ethanol dose-dependently reduced the gastric ulcer index. Thalidomide pretreatment significantly reduced the levels of pro-inflammatory cytokines [tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6], malondialdehyde (MDA) and myeloperoxidase (MPO) activity. In addition, thalidomide significantly inhibited ethanol-induced nitric oxide (NO) overproduction in gastric tissue. Histological observations showed that ethanol-induced gastric mucosal damage was attenuated by thalidomide pretreatment. It seems that thalidomide as an anti-inflammatory agent may have a protective effect against alcohol-induced mucosal damage by inhibition of neutrophil infiltration and reducing the production of nitric oxide and inflammatory cytokines in gastric tissue.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :کیوان امیرشاهرخی
نویسنده :علیرضا خلیلی
Additional Information:IF: 2.618 Indexed in: ISI, PubMed/Medline, Scopus, Embase
Uncontrolled Keywords:آسیب موکوسی معده،اتانول، تالیدوماید
کلیدواژه ها (انگلیسی):Thalidomide, Gastric mucosal damage, Ethanol , Thalidomide , Inflammation , Nitric oxide
Subjects:QV pharmacology
WI Digestive System
Divisions:School of Pharmacy > Department of Pharmacology
ID Code:6617
Deposited By: Dr Kivan Amir Shahrikhi
Deposited On:06 Feb 1394 03:30
Last Modified:10 May 1401 12:54

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